| ORD–SFO | Chicago – San Francisco | 888 |
| PDX–SEA | Portland – Seattle | 630 |
| CVG–EWR | Cincinnati / Covington – Newark | 508 |
| MIA–UIO | Miami – Quito | 478 |
| PTY–SJO | Tocumen – San José (Alajuela) | 457 |
| CVG–JFK | Cincinnati / Covington – New York | 452 |
| ATL–CVG | Atlanta – Cincinnati / Covington | 359 |
| CVG–MIA | Cincinnati / Covington – Miami | 345 |
| MIA–SJO | Miami – San José (Alajuela) | 283 |
| IAH–SAT | Houston – San Antonio | 260 |
| CVG–DFW | Cincinnati / Covington – Dallas-Fort Worth | 238 |
| CVG–MSP | Cincinnati / Covington – Minneapolis | 235 |
| CVG–IAH | Cincinnati / Covington – Houston | 225 |
| CLT–CVG | Charlotte – Cincinnati / Covington | 223 |
| CVG–MCO | Cincinnati / Covington – Orlando | 181 |
| CVG–SEA | Cincinnati / Covington – Seattle | 162 |
| CVG–LAS | Cincinnati / Covington – Las Vegas | 148 |
| BWI–CVG | Baltimore – Cincinnati / Covington | 126 |
| CVG–LAX | Cincinnati / Covington – Los Angeles | 118 |
| CVG–PHX | Cincinnati / Covington – Phoenix | 112 |
| CCS–MIA | Maiquetía – Miami | 110 |
| CVG–SJU | Cincinnati / Covington – San Juan | 95 |
| CVG–PDX | Cincinnati / Covington – Portland | 90 |
| CVG–TPA | Cincinnati / Covington – Tampa | 88 |
| ONT–RFD | Ontario – Chicago/Rockford | 81 |
| CVG–EMA | Cincinnati / Covington – Nottingham, Leicestershire | 76 |
| CVG–SCK | Cincinnati / Covington – Stockton | 74 |
| CVG–ONT | Cincinnati / Covington – Ontario | 72 |
| BDL–RFD | Hartford – Chicago/Rockford | 70 |
| AFW–SEA | AFW – Seattle | 64 |
| CVG–JAX | Cincinnati / Covington – Jacksonville | 58 |
| CVG–SFO | Cincinnati / Covington – San Francisco | 53 |
| MIA–RFD | Miami – Chicago/Rockford | 52 |
| CVG–YHM | Cincinnati / Covington – Hamilton | 47 |
| ABE–CVG | Allentown/Bethlehem – Cincinnati / Covington | 46 |
| CVG–STL | Cincinnati / Covington – St Louis | 45 |
| RFD–SEA | Chicago/Rockford – Seattle | 43 |
| JFK–RFD | New York – Chicago/Rockford | 43 |
| ABE–ILN | Allentown/Bethlehem – ILN | 42 |
| MHT–RFD | Manchester – Chicago/Rockford | 42 |
| AFW–MIA | AFW – Miami | 39 |
| CVG–MHT | Cincinnati / Covington – Manchester | 38 |
| CVG–RIC | Cincinnati / Covington – Richmond | 38 |
| CVG–ELP | Cincinnati / Covington – El Paso | 35 |
| CVG–RFD | Cincinnati / Covington – Chicago/Rockford | 33 |
| BDL–ILN | Hartford – ILN | 33 |
| AFW–CVG | AFW – Cincinnati / Covington | 28 |
| CLT–ILN | Charlotte – ILN | 28 |
| CVG–TUL | Cincinnati / Covington – Tulsa | 28 |
| ILN–RIC | ILN – Richmond | 25 |
| CVG–GSO | Cincinnati / Covington – Greensboro | 21 |
| SCK–SEA | Stockton – Seattle | 18 |
| RFD–SCK | Chicago/Rockford – Stockton | 18 |
| CVG–SJO | Cincinnati / Covington – San José (Alajuela) | 16 |
| SJU–UIO | San Juan – Quito | 13 |
| MIA–VLN | Miami – Valencia | 12 |
| OMA–TUL | Omaha – Tulsa | 7 |
| NBW–NGU | NBW – NGU | 6 |
| LAL–MIA | Lakeland – Miami | 5 |
| COS–CVG | Colorado Springs – Cincinnati / Covington | 5 |
| CVG–ILN | Cincinnati / Covington – ILN | 5 |
| CVG–NGU | Cincinnati / Covington – NGU | 2 |
| MIA–NGUonce | Miami – NGU | 1 |
| CCS–UIOonce | Maiquetía – Quito | 1 |
| CVG–RNOonce | Cincinnati / Covington – Reno | 1 |