| ATH–TLV | Spata-Artemida – Tel Aviv | 682 |
| OSL–SVG | Oslo (Gardermoen) – Stavanger | 586 |
| ATH–JTR | Spata-Artemida – Santorini Island | 579 |
| ATH–LCA | Spata-Artemida – Larnaca | 561 |
| ATH–SKG | Spata-Artemida – Thessaloniki | 485 |
| ATH–LHR | Spata-Artemida – London | 451 |
| BOO–OSL | Bodø – Oslo (Gardermoen) | 425 |
| ATH–HER | Spata-Artemida – Heraklion | 414 |
| HER–TLV | Heraklion – Tel Aviv | 389 |
| ATH–FCO | Spata-Artemida – Rome | 370 |
| RHO–TLV | Rhodes – Tel Aviv | 322 |
| ATH–CDG | Spata-Artemida – Paris (Roissy-en-France, Val-d'Oise) | 316 |
| ATH–IST | Spata-Artemida – Istanbul | 303 |
| ATH–MAD | Spata-Artemida – Madrid | 300 |
| ATH–CHQ | Spata-Artemida – Souda | 290 |
| ATH–MUC | Spata-Artemida – Munich | 287 |
| ATH–JMK | Spata-Artemida – Mykonos | 261 |
| ATH–RHO | Spata-Artemida – Rhodes | 259 |
| AMS–ATH | Amsterdam – Spata-Artemida | 251 |
| FRA–HER | Frankfurt am Main – Heraklion | 246 |
| ATH–FRA | Spata-Artemida – Frankfurt am Main | 239 |
| ATH–KGS | Spata-Artemida – Kos Island | 223 |
| ATH–MXP | Spata-Artemida – Ferno (VA) | 218 |
| ATH–CAI | Spata-Artemida – Cairo | 217 |
| ATH–ZRH | Spata-Artemida – Zurich | 215 |
| HER–ZRH | Heraklion – Zurich | 199 |
| ATH–JKH | Spata-Artemida – Chios Island | 196 |
| ATH–MJT | Spata-Artemida – Mytilene | 193 |
| HER–MUC | Heraklion – Munich | 186 |
| ATH–CFU | Spata-Artemida – Kerkyra (Corfu) | 186 |
| ATH–BCN | Spata-Artemida – Barcelona | 180 |
| ATH–BRU | Spata-Artemida – Zaventem | 174 |
| ATH–CPH | Spata-Artemida – Copenhagen | 165 |
| ATH–VIE | Spata-Artemida – Vienna | 163 |
| SKG–TLV | Thessaloniki – Tel Aviv | 162 |
| ATH–AXD | Spata-Artemida – Alexandroupolis | 162 |
| ATH–LGW | Spata-Artemida – London | 160 |
| ATH–WAW | Spata-Artemida – Warsaw | 155 |
| BGO–KRS | Bergen – Kristiansand(Kjevik) | 152 |
| ATH–BER | Spata-Artemida – Berlin | 142 |
| ATH–EFL | Spata-Artemida – Kefallinia Island | 142 |
| ATH–LIS | Spata-Artemida – Lisbon | 141 |
| ATH–OTP | Spata-Artemida – Otopeni | 134 |
| HER–SKG | Heraklion – Thessaloniki | 128 |
| ATH–TIA | Spata-Artemida – Rinas | 127 |
| ATH–GVA | Spata-Artemida – Geneva | 121 |
| ATH–DUS | Spata-Artemida – Düsseldorf | 118 |
| LCA–SKG | Larnaca – Thessaloniki | 118 |
| ATH–SMI | Spata-Artemida – Samos Island | 117 |
| MUC–SKG | Munich – Thessaloniki | 114 |
| FRA–SKG | Frankfurt am Main – Thessaloniki | 109 |
| DUS–SKG | Düsseldorf – Thessaloniki | 107 |
| ATH–BEG | Spata-Artemida – Belgrade | 107 |
| ARN–ATH | Stockholm – Spata-Artemida | 101 |
| ATH–VCE | Spata-Artemida – Venezia (VE) | 98 |
| BER–SKG | Berlin – Thessaloniki | 91 |
| ATH–MAN | Spata-Artemida – Manchester, Greater Manchester | 87 |
| ATH–PRG | Spata-Artemida – Prague | 83 |
| ATH–MLA | Spata-Artemida – Valletta | 83 |
| ATH–LYS | Spata-Artemida – Colombier-Saugnieu, Rhône | 82 |
| SKG–STR | Thessaloniki – Stuttgart | 82 |
| ATH–NAP | Spata-Artemida – Napoli | 81 |
| CDG–HER | Paris (Roissy-en-France, Val-d'Oise) – Heraklion | 79 |
| ATH–BUD | Spata-Artemida – Budapest | 79 |
| ATH–SOF | Spata-Artemida – Sofia | 78 |
| CHQ–OSL | Souda – Oslo (Gardermoen) | 76 |
| ATH–LXS | Spata-Artemida – Limnos Island | 76 |
| ATH–BLQ | Spata-Artemida – Bologna | 76 |
| ATH–DUB | Spata-Artemida – Dublin | 76 |
| ATH–OSL | Spata-Artemida – Oslo (Gardermoen) | 72 |
| ATH–IOA | Spata-Artemida – Ioannina | 70 |
| ATH–BEY | Spata-Artemida – Beirut | 70 |
| RHO–SKG | Rhodes – Thessaloniki | 70 |
| SKG–ZRH | Thessaloniki – Zurich | 69 |
| ATH–TBS | Spata-Artemida – Tbilisi | 68 |
| ATH–HAM | Spata-Artemida – Hamburg | 66 |
| ATH–NCE | Spata-Artemida – Nice, Alpes-Maritimes | 66 |
| BUD–RHO | Budapest – Rhodes | 66 |
| ATH–AUH | Spata-Artemida – Abu Dhabi | 64 |
| MJT–SKG | Mytilene – Thessaloniki | 61 |
| ATH–PFO | Spata-Artemida – Paphos | 61 |
| AMM–ATH | Amman – Spata-Artemida | 60 |
| IST–SKG | Istanbul – Thessaloniki | 58 |
| CHQ–SKG | Souda – Thessaloniki | 58 |
| ATH–KVA | Spata-Artemida – Kavala | 58 |
| ATH–MRS | Spata-Artemida – Marignane, Bouches-du-Rhône | 54 |
| HER–RHO | Heraklion – Rhodes | 53 |
| ATH–STR | Spata-Artemida – Stuttgart | 51 |
| ATH–RUH | Spata-Artemida – Riyadh | 46 |
| JMK–SKG | Mykonos – Thessaloniki | 46 |
| ATH–KRK | Spata-Artemida – Balice | 45 |
| ATH–DBV | Spata-Artemida – Dubrovnik | 42 |
| ATH–CTA | Spata-Artemida – Catania | 42 |
| HER–IST | Heraklion – Istanbul | 41 |
| ATH–EVN | Spata-Artemida – Yerevan | 40 |
| PAS–SKG | Paros – Thessaloniki | 38 |
| HER–LCA | Heraklion – Larnaca | 38 |
| AGP–ATH | Málaga – Spata-Artemida | 37 |
| OSL–RHO | Oslo (Gardermoen) – Rhodes | 37 |
| CHQ–WRO | Souda – Wrocław | 37 |
| FCO–SKG | Rome – Thessaloniki | 37 |
| ATH–BIO | Spata-Artemida – Bilbao | 36 |
| BLQ–HER | Bologna – Heraklion | 35 |
| NUE–SKG | Nuremberg – Thessaloniki | 34 |
| HAM–SKG | Hamburg – Thessaloniki | 34 |
| ATH–EDI | Spata-Artemida – Ingliston, Edinburgh | 33 |
| ATH–BOD | Spata-Artemida – Bordeaux | 33 |
| ATH–RMO | Spata-Artemida – Chişinău | 33 |
| ATH–NTE | Spata-Artemida – Nantes | 32 |
| CHQ–TLV | Souda – Tel Aviv | 32 |
| MXP–SKG | Ferno (VA) – Thessaloniki | 31 |
| KGS–SKG | Kos Island – Thessaloniki | 31 |
| HER–TIA | Heraklion – Rinas | 30 |
| ATH–RIX | Spata-Artemida – Riga | 29 |
| ADB–ATH | Gaziemir – Spata-Artemida | 29 |
| ATH–JED | Spata-Artemida – Jeddah | 28 |
| RHO–SVG | Rhodes – Stavanger | 28 |
| JTR–SKG | Santorini Island – Thessaloniki | 28 |
| ATH–HEL | Spata-Artemida – Helsinki (Vantaa) | 26 |
| ATH–RAK | Spata-Artemida – Marrakesh | 26 |