| LAX–SEA | Los Angeles – Seattle | 1,252 |
| BKK–NRT | Bangkok – Narita | 423 |
| DWC–HKG | Dubai(Jebel Ali) – Hong Kong | 413 |
| HKG–LAX | Hong Kong – Los Angeles | 380 |
| FRA–JFK | Frankfurt am Main – New York | 320 |
| FRA–ORD | Frankfurt am Main – Chicago | 310 |
| BKK–SZX | Bangkok – Shenzhen | 276 |
| DFW–YYZ | Dallas-Fort Worth – Toronto | 265 |
| BKK–DXB | Bangkok – Dubai | 256 |
| FRA–YYZ | Frankfurt am Main – Toronto | 240 |
| FRA–LAX | Frankfurt am Main – Los Angeles | 201 |
| DEL–FRA | New Delhi – Frankfurt am Main | 183 |
| ATL–FRA | Atlanta – Frankfurt am Main | 175 |
| CVG–LEJ | Cincinnati / Covington – Schkeuditz | 169 |
| DXB–HKG | Dubai – Hong Kong | 154 |
| DFW–FRA | Dallas-Fort Worth – Frankfurt am Main | 129 |
| BOM–FRA | Mumbai – Frankfurt am Main | 127 |
| FRA–IAH | Frankfurt am Main – Houston | 124 |
| FRA–SEA | Frankfurt am Main – Seattle | 122 |
| CVG–LAX | Cincinnati / Covington – Los Angeles | 118 |
| BKK–BLR | Bangkok – Bengaluru | 116 |
| BRU–CVG | Zaventem – Cincinnati / Covington | 101 |
| CVG–NRT | Cincinnati / Covington – Narita | 93 |
| HKG–MXP | Hong Kong – Ferno (VA) | 91 |
| FRA–TPE | Frankfurt am Main – Taoyuan | 88 |
| HKG–RUH | Hong Kong – Riyadh | 86 |
| BLR–HKG | Bengaluru – Hong Kong | 82 |
| CVG–EMA | Cincinnati / Covington – Nottingham, Leicestershire | 76 |
| EMA–LEJ | Nottingham, Leicestershire – Schkeuditz | 75 |
| LAX–SZX | Los Angeles – Shenzhen | 73 |
| FRA–HAN | Frankfurt am Main – Hanoi (Soc Son) | 73 |
| FRA–SGN | Frankfurt am Main – Ho Chi Minh City | 71 |
| HKG–LEJ | Hong Kong – Schkeuditz | 69 |
| BLR–FRA | Bengaluru – Frankfurt am Main | 64 |
| FRA–TAS | Frankfurt am Main – Tashkent | 64 |
| BRU–LEJ | Zaventem – Schkeuditz | 63 |
| FRA–HYD | Frankfurt am Main – Hyderabad | 62 |
| LEJ–PVG | Schkeuditz – Shanghai (Pudong) | 58 |
| ALA–FRA | Almaty – Frankfurt am Main | 58 |
| DXB–LAX | Dubai – Los Angeles | 58 |
| DWC–FRA | Dubai(Jebel Ali) – Frankfurt am Main | 56 |
| BRU–HKG | Zaventem – Hong Kong | 54 |
| DXB–HAN | Dubai – Hanoi (Soc Son) | 54 |
| LEJ–TLV | Schkeuditz – Tel Aviv | 53 |
| CVG–HKG | Cincinnati / Covington – Hong Kong | 44 |
| LEJ–MXP | Schkeuditz – Ferno (VA) | 38 |
| LAX–LEJ | Los Angeles – Schkeuditz | 36 |
| BKK–LEJ | Bangkok – Schkeuditz | 34 |
| FRA–LEJ | Frankfurt am Main – Schkeuditz | 34 |
| LEJ–SIN | Schkeuditz – Singapore | 32 |
| DXB–LEJ | Dubai – Schkeuditz | 31 |
| DWC–TPE | Dubai(Jebel Ali) – Taoyuan | 31 |
| BAH–CVG | Manama – Cincinnati / Covington | 30 |
| BAH–HKG | Manama – Hong Kong | 30 |
| BAH–LEJ | Manama – Schkeuditz | 28 |
| BLR–LEJ | Bengaluru – Schkeuditz | 26 |
| ICN–LEJ | Seoul – Schkeuditz | 25 |
| LEJ–NRT | Schkeuditz – Narita | 24 |
| HKG–TLV | Hong Kong – Tel Aviv | 21 |
| LEJ–SZX | Schkeuditz – Shenzhen | 19 |
| DEL–LEJ | New Delhi – Schkeuditz | 17 |
| DWC–LEJ | Dubai(Jebel Ali) – Schkeuditz | 14 |
| LEJ–RUH | Schkeuditz – Riyadh | 12 |
| HAN–LEJ | Hanoi (Soc Son) – Schkeuditz | 9 |
| HKG–TAS | Hong Kong – Tashkent | 9 |
| CVG–PVG | Cincinnati / Covington – Shanghai (Pudong) | 8 |
| LEJ–TPE | Schkeuditz – Taoyuan | 7 |
| DXB–EMA | Dubai – Nottingham, Leicestershire | 7 |
| IAH–SVG | Houston – Stavanger | 4 |
| BLR–EMA | Bengaluru – Nottingham, Leicestershire | 4 |
| EMA–FRA | Nottingham, Leicestershire – Frankfurt am Main | 3 |
| CVG–DEL | Cincinnati / Covington – New Delhi | 3 |
| BAH–LAX | Manama – Los Angeles | 2 |
| BAH–SZXonce | Manama – Shenzhen | 1 |
| CVG–FRAonce | Cincinnati / Covington – Frankfurt am Main | 1 |
