| BNE–SYD | Brisbane – Sydney (Mascot) | 1,477 |
| MEX–MTY | Mexico City – Monterrey | 1,028 |
| CUN–MEX | Cancún – Mexico City | 885 |
| GDL–MEX | Guadalajara – Mexico City | 831 |
| MEX–TIJ | Mexico City – Tijuana | 680 |
| BNE–CNS | Brisbane – Cairns | 611 |
| MEX–MID | Mexico City – Mérida | 527 |
| BNE–TSV | Brisbane – Townsville | 480 |
| GDL–LAX | Guadalajara – Los Angeles | 422 |
| IAH–MEX | Houston – Mexico City | 418 |
| CBR–SYD | Canberra – Sydney (Mascot) | 406 |
| LAX–MEX | Los Angeles – Mexico City | 379 |
| MEX–PTY | Mexico City – Tocumen | 365 |
| BOG–MEX | Bogota – Mexico City | 362 |
| MEX–ORD | Mexico City – Chicago | 357 |
| MAD–MEX | Madrid – Mexico City | 351 |
| DFW–MEX | Dallas-Fort Worth – Mexico City | 338 |
| MEX–PVR | Mexico City – Puerto Vallarta | 335 |
| CUN–NLU | Cancún – Mexico City | 306 |
| JFK–MEX | New York – Mexico City | 305 |
| MEX–MIA | Mexico City – Miami | 303 |
| GDL–NLU | Guadalajara – Mexico City | 293 |
| HMO–MEX | Hermosillo – Mexico City | 289 |
| MEX–SJD | Mexico City – San José del Cabo | 282 |
| CJS–MEX | Ciudad Juárez – Mexico City | 270 |
| CUU–MEX | Chihuahua – Mexico City | 259 |
| MEX–OAX | Mexico City – Oaxaca | 251 |
| MEX–SFO | Mexico City – San Francisco | 248 |
| MEX–VSA | Mexico City – Villahermosa | 238 |
| MTY–NLU | Monterrey – Mexico City | 218 |
| MEX–VER | Mexico City – Veracruz | 217 |
| MEX–YYZ | Mexico City – Toronto | 215 |
| MEX–TRC | Mexico City – Torreón | 204 |
| MEX–TGZ | Mexico City – Tuxtla Gutiérrez | 203 |
| LIM–MEX | Lima – Mexico City | 202 |
| MID–NLU | Mérida – Mexico City | 198 |
| MEX–SJO | Mexico City – San José (Alajuela) | 193 |
| BJX–MEX | Silao – Mexico City | 192 |
| CDG–MEX | Paris (Roissy-en-France, Val-d'Oise) – Mexico City | 184 |
| DBO–SYD | Dubbo – Sydney (Mascot) | 180 |
| MCO–MEX | Orlando – Mexico City | 174 |
| AGU–MEX | Aguascalientes – Mexico City | 173 |
| MEX–MZT | Mexico City – Mazatlàn | 168 |
| SYD–WGA | Sydney (Mascot) – Forest Hill | 164 |
| EWR–MEX | Newark – Mexico City | 162 |
| MEX–YVR | Mexico City – Vancouver | 159 |
| MID–MTY | Mérida – Monterrey | 157 |
| LAS–MEX | Las Vegas – Mexico City | 156 |
| DEN–MEX | Denver – Mexico City | 153 |
| PQQ–SYD | Port Macquarie – Sydney (Mascot) | 153 |
| CTM–MEX | Chetumal – Mexico City | 149 |
| MEX–SLP | Mexico City – San Luis Potosí | 147 |
| LAP–MEX | La Paz – Mexico City | 146 |
| GRU–MEX | São Paulo – Mexico City | 142 |
| GUA–MEX | Guatemala City – Mexico City | 142 |
| MEX–PXM | Mexico City – Puerto Escondido | 137 |
| MEX–MXL | Mexico City – Mexicali | 133 |
| MEX–SAT | Mexico City – San Antonio | 128 |
| LMM–MEX | Los Mochis – Mexico City | 124 |
| MEX–SAL | Mexico City – San Salvador (San Luis Talpa) | 119 |
| LHR–MEX | London – Mexico City | 118 |
| CUL–MEX | Culiacán – Mexico City | 117 |
| MEX–YUL | Mexico City – Montréal | 115 |
| AMS–MEX | Amsterdam – Mexico City | 115 |
| ACA–MEX | Acapulco – Mexico City | 115 |
| HUX–MEX | Huatulco – Mexico City | 115 |
| IAD–MEX | Dulles – Mexico City | 113 |
| CZM–MEX | Cozumel – Mexico City | 111 |
| DGO–MEX | Durango – Mexico City | 110 |
| MEX–ZIH | Mexico City – Ixtapa | 110 |
| BCN–MEX | Barcelona – Mexico City | 108 |
| MEX–TAP | Mexico City – Tapachula | 106 |
| NLU–PVR | Mexico City – Puerto Vallarta | 106 |
| NLU–TQO | Mexico City – Tulum | 104 |
| MEX–PHX | Mexico City – Phoenix | 104 |
| MEX–TAM | Mexico City – Ciudad Madero | 101 |
| MEX–MTT | Mexico City – Cosoleacaque | 98 |
| ATL–MTY | Atlanta – Monterrey | 96 |
| MEX–ZLO | Mexico City – Manzanillo | 94 |
| CEN–MEX | Ciudad Obregón – Mexico City | 92 |
| MEX–NRT | Mexico City – Narita | 89 |
| MEX–QRO | Mexico City – Querétaro | 89 |
| MDE–MEX | Medellín – Mexico City | 88 |
| ATL–QRO | Atlanta – Querétaro | 88 |
| MEX–REX | Mexico City – Reynosa | 87 |
| MAD–MTY | Madrid – Monterrey | 79 |
| CPE–MEX | Campeche – Mexico City | 77 |
| GDL–SLC | Guadalajara – Salt Lake City | 75 |
| MEX–ZCL | Mexico City – Zacatecas | 71 |
| CME–MEX | Ciudad del Carmen – Mexico City | 66 |
| GDL–MAD | Guadalajara – Madrid | 61 |
| FCO–MEX | Rome – Mexico City | 60 |
| NLU–VER | Mexico City – Veracruz | 60 |
| EZE–MEX | Buenos Aires (Ezeiza) – Mexico City | 59 |
| MEX–PUJ | Mexico City – Punta Cana | 59 |
| MEX–SEA | Mexico City – Seattle | 56 |
| BOS–MEX | Boston – Mexico City | 55 |
| CTG–MEX | Cartagena – Mexico City | 54 |
| MEX–SDQ | Mexico City – Santo Domingo | 53 |
| MEX–RDU | Mexico City – Raleigh/Durham | 53 |
| DTW–MTY | Detroit – Monterrey | 52 |
| ATL–BJX | Atlanta – Silao | 52 |
| NLU–OAX | Mexico City – Oaxaca | 52 |
| MEX–TPA | Mexico City – Tampa | 50 |
| HAV–MEX | Havana – Mexico City | 49 |
| AUS–MEX | Austin – Mexico City | 48 |
| CLQ–MEX | Colima – Mexico City | 46 |
| DGO–NLU | Durango – Mexico City | 45 |
| MEX–TPQ | Mexico City – Tepic | 45 |
| DTW–QRO | Detroit – Querétaro | 42 |
| MEX–PHL | Mexico City – Philadelphia | 42 |
| MEX–TQO | Mexico City – Tulum | 42 |
| CUN–HAV | Cancún – Havana | 40 |
| MEX–MLM | Mexico City – Morelia | 39 |
| MIM–SYD | Merimbula – Sydney (Mascot) | 37 |
| MRZ–SYD | Moree – Sydney (Mascot) | 36 |
| MEX–NLD | Mexico City – Nuevo Laredo | 36 |
| MEX–XPL | Mexico City – Palmerola | 36 |
| MEX–MGA | Mexico City – Managua | 35 |
| CDG–MTY | Paris (Roissy-en-France, Val-d'Oise) – Monterrey | 34 |
