| GDL–MEX | Guadalajara – Mexico City | 831 |
| MEX–PTY | Mexico City – Tocumen | 365 |
| DFW–MEX | Dallas-Fort Worth – Mexico City | 338 |
| MEX–PVR | Mexico City – Puerto Vallarta | 335 |
| MEX–SJD | Mexico City – San José del Cabo | 282 |
| MEX–OAX | Mexico City – Oaxaca | 251 |
| MEX–VSA | Mexico City – Villahermosa | 238 |
| MTY–NLU | Monterrey – Mexico City | 218 |
| MEX–VER | Mexico City – Veracruz | 217 |
| MEX–TRC | Mexico City – Torreón | 204 |
| MEX–TGZ | Mexico City – Tuxtla Gutiérrez | 203 |
| MID–NLU | Mérida – Mexico City | 198 |
| BJX–MEX | Silao – Mexico City | 192 |
| AGU–MEX | Aguascalientes – Mexico City | 173 |
| MEX–MZT | Mexico City – Mazatlàn | 168 |
| CTM–MEX | Chetumal – Mexico City | 149 |
| MEX–SLP | Mexico City – San Luis Potosí | 147 |
| LAP–MEX | La Paz – Mexico City | 146 |
| GUA–MEX | Guatemala City – Mexico City | 142 |
| LMM–MEX | Los Mochis – Mexico City | 124 |
| CUL–MEX | Culiacán – Mexico City | 117 |
| ACA–MEX | Acapulco – Mexico City | 115 |
| HUX–MEX | Huatulco – Mexico City | 115 |
| CZM–MEX | Cozumel – Mexico City | 111 |
| DGO–MEX | Durango – Mexico City | 110 |
| MEX–ZIH | Mexico City – Ixtapa | 110 |
| MEX–TAP | Mexico City – Tapachula | 106 |
| NLU–PVR | Mexico City – Puerto Vallarta | 106 |
| NLU–TQO | Mexico City – Tulum | 104 |
| MEX–TAM | Mexico City – Ciudad Madero | 101 |
| MEX–MTT | Mexico City – Cosoleacaque | 98 |
| ATL–MTY | Atlanta – Monterrey | 96 |
| MEX–ZLO | Mexico City – Manzanillo | 94 |
| CEN–MEX | Ciudad Obregón – Mexico City | 92 |
| MEX–QRO | Mexico City – Querétaro | 89 |
| ATL–QRO | Atlanta – Querétaro | 88 |
| CPE–MEX | Campeche – Mexico City | 77 |
| MEX–ZCL | Mexico City – Zacatecas | 71 |
| CME–MEX | Ciudad del Carmen – Mexico City | 66 |
| NLU–VER | Mexico City – Veracruz | 60 |
| MEX–RDU | Mexico City – Raleigh/Durham | 53 |
| DTW–MTY | Detroit – Monterrey | 52 |
| ATL–BJX | Atlanta – Silao | 52 |
| NLU–OAX | Mexico City – Oaxaca | 52 |
| CLQ–MEX | Colima – Mexico City | 46 |
| DGO–NLU | Durango – Mexico City | 45 |
| MEX–TPQ | Mexico City – Tepic | 45 |
| DTW–QRO | Detroit – Querétaro | 42 |
| MEX–TQO | Mexico City – Tulum | 42 |
| MEX–MLM | Mexico City – Morelia | 39 |
| MEX–NLD | Mexico City – Nuevo Laredo | 36 |
| MEX–XPL | Mexico City – Palmerola | 36 |
| MEX–MGA | Mexico City – Managua | 35 |
| MEX–SAP | Mexico City – San Pedro Sula | 31 |
| MAM–MEX | Matamoros – Mexico City | 21 |
| FTW–MEXonce | Fort Worth – Mexico City | 1 |
| MEX–SJXonce | Mexico City – SJX | 1 |
