| JFK–LAX | New York – Los Angeles | 1,688 |
| LAX–SFO | Los Angeles – San Francisco | 1,360 |
| LGA–ORD | New York – Chicago | 1,357 |
| LAX–SEA | Los Angeles – Seattle | 1,252 |
| BOS–DCA | Boston – Washington | 1,176 |
| ATL–LGA | Atlanta – New York | 1,157 |
| LAX–ORD | Los Angeles – Chicago | 1,154 |
| JFK–LHR | New York – London | 1,135 |
| JFK–SFO | New York – San Francisco | 1,110 |
| BOS–ORD | Boston – Chicago | 1,101 |
| LGA–YYZ | New York – Toronto | 1,075 |
| DFW–ORD | Dallas-Fort Worth – Chicago | 1,041 |
| BOS–LGA | Boston – New York | 1,032 |
| DCA–ORD | Washington – Chicago | 978 |
| PHX–SEA | Phoenix – Seattle | 925 |
| DEN–PHX | Denver – Phoenix | 896 |
| LAX–PHX | Los Angeles – Phoenix | 895 |
| ORD–SFO | Chicago – San Francisco | 888 |
| DEN–LAX | Denver – Los Angeles | 876 |
| DFW–LAX | Dallas-Fort Worth – Los Angeles | 870 |
| LAS–LAX | Las Vegas – Los Angeles | 869 |
| ORD–SEA | Chicago – Seattle | 847 |
| ATL–ORD | Atlanta – Chicago | 833 |
| ORD–YYZ | Chicago – Toronto | 830 |
| DEN–ORD | Denver – Chicago | 824 |
| HNL–LAX | Honolulu, Oahu – Los Angeles | 822 |
| ATL–DCA | Atlanta – Washington | 811 |
| LAX–SMF | Los Angeles – Sacramento | 800 |
| BOS–LAX | Boston – Los Angeles | 799 |
| DFW–LGA | Dallas-Fort Worth – New York | 779 |
| ATL–MCO | Atlanta – Orlando | 777 |
| BOS–PHL | Boston – Philadelphia | 758 |
| ANC–ORD | Anchorage – Chicago | 739 |
| ORD–PHX | Chicago – Phoenix | 739 |
| ATL–LAX | Atlanta – Los Angeles | 736 |
| IAH–ORD | Houston – Chicago | 733 |
| BNA–ORD | Nashville – Chicago | 731 |
| ATL–PHL | Atlanta – Philadelphia | 728 |
| DTW–ORD | Detroit – Chicago | 727 |
| ORD–PHL | Chicago – Philadelphia | 719 |
| BOS–JFK | Boston – New York | 713 |
| MSP–ORD | Minneapolis – Chicago | 710 |
| CLT–ORD | Charlotte – Chicago | 706 |
| EWR–ORD | Newark – Chicago | 700 |
| HNL–LIH | Honolulu, Oahu – Lihue, Kauai | 698 |
| MCO–PHL | Orlando – Philadelphia | 683 |
| BNA–LGA | Nashville – New York | 682 |
| CMH–ORD | Columbus – Chicago | 673 |
| DFW–SFO | Dallas-Fort Worth – San Francisco | 668 |
| LGA–MIA | New York – Miami | 663 |
| JFK–LAS | New York – Las Vegas | 662 |
| DFW–MIA | Dallas-Fort Worth – Miami | 662 |
| DFW–LAS | Dallas-Fort Worth – Las Vegas | 659 |
| DEN–DFW | Denver – Dallas-Fort Worth | 653 |
| DFW–SEA | Dallas-Fort Worth – Seattle | 652 |
| DFW–PHX | Dallas-Fort Worth – Phoenix | 649 |
| BNA–DCA | Nashville – Washington | 642 |
| ATL–DFW | Atlanta – Dallas-Fort Worth | 641 |
| PHX–SAN | Phoenix – San Diego | 633 |
| JFK–ORD | New York – Chicago | 629 |
| CVG–ORD | Cincinnati / Covington – Chicago | 628 |
| MCI–ORD | Kansas City – Chicago | 625 |
| DFW–IAH | Dallas-Fort Worth – Houston | 625 |
| ORD–TVC | Chicago – Traverse City | 616 |
| IND–ORD | Indianapolis – Chicago | 614 |
| LAS–ORD | Las Vegas – Chicago | 612 |
| CLT–LGA | Charlotte – New York | 611 |
| LGA–STL | New York – St Louis | 600 |
| JFK–RDU | New York – Raleigh/Durham | 600 |
| MCO–ORD | Orlando – Chicago | 596 |
| DFW–MCO | Dallas-Fort Worth – Orlando | 590 |
| LGA–RDU | New York – Raleigh/Durham | 588 |
| ATL–MIA | Atlanta – Miami | 584 |
| DCA–LGA | Washington – New York | 583 |
| BOS–CLT | Boston – Charlotte | 581 |
| LAS–PHX | Las Vegas – Phoenix | 578 |
| CLT–EWR | Charlotte – Newark | 572 |
| PHX–SFO | Phoenix – San Francisco | 571 |
| CLT–DFW | Charlotte – Dallas-Fort Worth | 570 |
| CJU–TAE | Jeju City – Daegu | 563 |
| JFK–MIA | New York – Miami | 562 |
| ORD–SAN | Chicago – San Diego | 559 |
| CDG–JFK | Paris (Roissy-en-France, Val-d'Oise) – New York | 558 |
| DCA–MCO | Washington – Orlando | 548 |
| ORD–RDU | Chicago – Raleigh/Durham | 548 |
| ORD–XNA | Chicago – Fayetteville/Springdale/Rogers | 544 |
| DFW–SAN | Dallas-Fort Worth – San Diego | 543 |
| MIA–ORD | Miami – Chicago | 540 |
| ORD–STL | Chicago – St Louis | 539 |
| ORD–PIT | Chicago – Pittsburgh | 538 |
| LIM–MIA | Lima – Miami | 534 |
| MKE–ORD | Milwaukee – Chicago | 534 |
| IND–LGA | Indianapolis – New York | 531 |
| LAX–LHR | Los Angeles – London | 528 |
| ATL–CLT | Atlanta – Charlotte | 528 |
| MIA–PTY | Miami – Tocumen | 524 |
| FLL–LGA | Fort Lauderdale – New York | 521 |
| PHX–SLC | Phoenix – Salt Lake City | 521 |
| OKC–ORD | Oklahoma City – Chicago | 515 |
| MEM–ORD | Memphis – Chicago | 514 |
| CLE–ORD | Cleveland – Chicago | 512 |
| BNA–JFK | Nashville – New York | 509 |
| BOS–DFW | Boston – Dallas-Fort Worth | 508 |
| CMH–LGA | Columbus – New York | 508 |
| MSN–ORD | Madison – Chicago | 504 |
| IAH–LAX | Houston – Los Angeles | 500 |
| DEN–PDX | Denver – Portland | 497 |
| CLT–MCO | Charlotte – Orlando | 493 |
| DCA–MIA | Washington – Miami | 491 |
| DTW–LGA | Detroit – New York | 490 |
| DFW–EWR | Dallas-Fort Worth – Newark | 489 |
| LAX–PDX | Los Angeles – Portland | 489 |
| LAX–YVR | Los Angeles – Vancouver | 487 |
| AUS–DFW | Austin – Dallas-Fort Worth | 486 |
| CLT–IAD | Charlotte – Dulles | 485 |
| GRR–ORD | Grand Rapids – Chicago | 483 |
| GRB–ORD | Green Bay – Chicago | 483 |
| DFW–PHL | Dallas-Fort Worth – Philadelphia | 481 |
| DFW–SAT | Dallas-Fort Worth – San Antonio | 479 |
| ORD–TUL | Chicago – Tulsa | 479 |