| YVR–YYC | Vancouver – Calgary | 1,420 |
| YEG–YVR | Edmonton – Vancouver | 849 |
| YEG–YYC | Edmonton – Calgary | 493 |
| MIA–UIO | Miami – Quito | 478 |
| YWG–YYC | Winnipeg – Calgary | 454 |
| YVR–YWG | Vancouver – Winnipeg | 349 |
| MDE–PTY | Medellín – Tocumen | 327 |
| YHZ–YYT | Halifax – St. John's | 294 |
| MIA–SDQ | Miami – Santo Domingo | 289 |
| GYE–PTY | Guayaquil – Tocumen | 269 |
| YHM–YYC | Hamilton – Calgary | 202 |
| KIN–MIA | Kingston – Miami | 184 |
| YEG–YWG | Edmonton – Winnipeg | 173 |
| YHM–YVR | Hamilton – Vancouver | 162 |
| NRT–YVR | Narita – Vancouver | 157 |
| YHM–YHZ | Hamilton – Halifax | 153 |
| LIM–UIO | Lima – Quito | 136 |
| YWG–YXE | Winnipeg – Saskatoon | 125 |
| MIA–VCP | Miami – Campinas | 122 |
| MIA–POS | Miami – Port of Spain | 120 |
| MIA–SAP | Miami – San Pedro Sula | 114 |
| CCS–MIA | Maiquetía – Miami | 110 |
| MEL–NAN | Melbourne – Nadi | 102 |
| BRU–CVG | Zaventem – Cincinnati / Covington | 101 |
| YEG–YHZ | Edmonton – Halifax | 97 |
| YFB–YOW | Iqaluit – Ottawa | 95 |
| MBJ–MIA | Montego Bay – Miami | 82 |
| YHM–YWG | Hamilton – Winnipeg | 80 |
| PVG–YVR | Shanghai (Pudong) – Vancouver | 78 |
| YHM–YOW | Hamilton – Ottawa | 78 |
| CVG–EMA | Cincinnati / Covington – Nottingham, Leicestershire | 76 |
| YEG–YHM | Edmonton – Hamilton | 70 |
| YQR–YWG | Regina – Winnipeg | 69 |
| GEO–POS | Georgetown – Port of Spain | 59 |
| LGG–TLV | Grâce-Hollogne – Tel Aviv | 50 |
| GUA–SAP | Guatemala City – San Pedro Sula | 50 |
| SDF–YHM | Louisville – Hamilton | 48 |
| CVG–YHM | Cincinnati / Covington – Hamilton | 47 |
| CVG–GDL | Cincinnati / Covington – Guadalajara | 46 |
| CVG–NLU | Cincinnati / Covington – Mexico City | 46 |
| YMX–YQM | Montréal – Moncton | 39 |
| ATL–GIG | Atlanta – Rio De Janeiro | 38 |
| CVG–YVR | Cincinnati / Covington – Vancouver | 35 |
| CVG–MTY | Cincinnati / Covington – Monterrey | 34 |
| SDF–YYZ | Louisville – Toronto | 33 |
| CVG–QRO | Cincinnati / Covington – Querétaro | 32 |
| CVG–YYC | Cincinnati / Covington – Calgary | 31 |
| SDF–YVR | Louisville – Vancouver | 30 |
| GDL–QRO | Guadalajara – Querétaro | 29 |
| KIN–SDQ | Kingston – Santo Domingo | 28 |
| YQR–YXE | Regina – Saskatoon | 28 |
| GYE–MDE | Guayaquil – Medellín | 27 |
| CVG–YMX | Cincinnati / Covington – Montréal | 26 |
| YQM–YYT | Moncton – St. John's | 19 |
| YHM–YQM | Hamilton – Moncton | 18 |
| YFB–YWG | Iqaluit – Winnipeg | 17 |
| YHM–YMX | Hamilton – Montréal | 16 |
| YMX–YWG | Montréal – Winnipeg | 12 |
| MIA–VLN | Miami – Valencia | 12 |
| YHZ–YMX | Halifax – Montréal | 11 |
| MIA–PBM | Miami – Paramaribo | 10 |
| CVG–PTY | Cincinnati / Covington – Tocumen | 9 |
| YHZ–YQM | Halifax – Moncton | 7 |
| SAP–SJO | San Pedro Sula – San José (Alajuela) | 5 |
| YMX–YYT | Montréal – St. John's | 5 |
| LGG–YHZ | Grâce-Hollogne – Halifax | 4 |
| LGG–YYT | Grâce-Hollogne – St. John's | 3 |
| CVG–YEG | Cincinnati / Covington – Edmonton | 3 |
| MGA–YHM | Managua – Hamilton | 3 |
| LCK–MGA | Columbus – Managua | 3 |
| LGG–YHM | Grâce-Hollogne – Hamilton | 3 |
| YHM–YQR | Hamilton – Regina | 3 |
| STN–YYZ | London, Essex – Toronto | 2 |
| STN–YHM | London, Essex – Hamilton | 2 |
| YFB–YHM | Iqaluit – Hamilton | 2 |
| BQK–YHM | Brunswick – Hamilton | 2 |
| ATL–YHM | Atlanta – Hamilton | 2 |
| STN–YMXonce | London, Essex – Montréal | 1 |
| MIA–YHMonce | Miami – Hamilton | 1 |
| GYR–YHMonce | GYR – Hamilton | 1 |
| GYR–LCKonce | GYR – Columbus | 1 |
| LAX–YHMonce | Los Angeles – Hamilton | 1 |
| ATL–VCPonce | Atlanta – Campinas | 1 |
| PHX–YHMonce | Phoenix – Hamilton | 1 |
| GDL–YHMonce | Guadalajara – Hamilton | 1 |
| CVG–YHZonce | Cincinnati / Covington – Halifax | 1 |