| DFW–ORD | Dallas-Fort Worth – Chicago | 1,041 |
| BKK–TPE | Bangkok – Taoyuan | 692 |
| ANC–HKG | Anchorage – Hong Kong | 688 |
| ATL–DFW | Atlanta – Dallas-Fort Worth | 641 |
| IND–ORD | Indianapolis – Chicago | 614 |
| ATL–MIA | Atlanta – Miami | 584 |
| JFK–MIA | New York – Miami | 562 |
| ATL–JFK | Atlanta – New York | 544 |
| MIA–ORD | Miami – Chicago | 540 |
| PEK–XMN | Beijing – Xiamen | 480 |
| IND–JFK | Indianapolis – New York | 350 |
| ATL–IND | Atlanta – Indianapolis | 337 |
| GIG–VCP | Rio De Janeiro – Campinas | 283 |
| IAH–MIA | Houston – Miami | 283 |
| SEA–YYC | Seattle – Calgary | 274 |
| IAH–IND | Houston – Indianapolis | 253 |
| CGK–HKG | Jakarta – Hong Kong | 228 |
| HAN–HKG | Hanoi (Soc Son) – Hong Kong | 211 |
| ATL–SJU | Atlanta – San Juan | 190 |
| HKG–PEN | Hong Kong – Penang | 168 |
| AMS–NBO | Amsterdam – Nairobi | 152 |
| ANC–LAX | Anchorage – Los Angeles | 131 |
| ANC–HAN | Anchorage – Hanoi (Soc Son) | 114 |
| AMS–MIA | Amsterdam – Miami | 83 |
| ANC–CGO | Anchorage – Zhengzhou | 75 |
| HKG–LUX | Hong Kong – Luxembourg | 62 |
| AMS–LUX | Amsterdam – Luxembourg | 58 |
| LUX–MAD | Luxembourg – Madrid | 56 |
| LAX–LUX | Los Angeles – Luxembourg | 55 |
| CGO–LUX | Zhengzhou – Luxembourg | 50 |
| LUX–ORD | Luxembourg – Chicago | 48 |
| ASB–LUX | Ashgabat – Luxembourg | 43 |
| ANC–GDL | Anchorage – Guadalajara | 41 |
| GYD–HKG | Baku – Hong Kong | 39 |
| BUD–GYD | Budapest – Baku | 35 |
| LUX–MXP | Luxembourg – Ferno (VA) | 34 |
| GDL–MIA | Guadalajara – Miami | 32 |
| AMS–UIO | Amsterdam – Quito | 28 |
| LUX–PVG | Luxembourg – Shanghai (Pudong) | 27 |
| GYD–LUX | Baku – Luxembourg | 26 |
| LUX–VCP | Luxembourg – Campinas | 26 |
| JFK–LUX | New York – Luxembourg | 24 |
| FLL–MIA | Fort Lauderdale – Miami | 24 |
| LUX–NLU | Luxembourg – Mexico City | 22 |
| IND–LUX | Indianapolis – Luxembourg | 20 |
| UIO–VCP | Quito – Campinas | 19 |
| ARN–LUX | Stockholm – Luxembourg | 19 |
| ATL–LUX | Atlanta – Luxembourg | 18 |
| BUD–LUX | Budapest – Luxembourg | 17 |
| LUX–NQZ | Luxembourg – Astana | 16 |
| LUX–MIA | Luxembourg – Miami | 16 |
| GYD–SIN | Baku – Singapore | 14 |
| LUX–SIN | Luxembourg – Singapore | 13 |
| DFW–LUX | Dallas-Fort Worth – Luxembourg | 13 |
| GDL–LUX | Guadalajara – Luxembourg | 13 |
| LUX–TPE | Luxembourg – Taoyuan | 13 |
| LUX–SEA | Luxembourg – Seattle | 12 |
| HAN–LUX | Hanoi (Soc Son) – Luxembourg | 12 |
| KUL–LUX | Sepang – Luxembourg | 11 |
| IAH–LUX | Houston – Luxembourg | 11 |
| BKK–LUX | Bangkok – Luxembourg | 11 |
| KMQ–ORD | Kanazawa – Chicago | 9 |
| IAH–PIK | Houston – Prestwick, South Ayrshire | 9 |
| LUX–STN | Luxembourg – London, Essex | 9 |
| HKG–MIA | Hong Kong – Miami | 9 |
| CGO–ORD | Zhengzhou – Chicago | 8 |
| HKG–MCT | Hong Kong – Muscat/Seeb | 8 |
| ICN–LUX | Seoul – Luxembourg | 8 |
| JNB–LUX | Johannesburg – Luxembourg | 8 |
| LUX–MCT | Luxembourg – Muscat/Seeb | 7 |
| LUX–XMN | Luxembourg – Xiamen | 7 |
| GIG–LUX | Rio De Janeiro – Luxembourg | 7 |
| LAX–MXP | Los Angeles – Ferno (VA) | 6 |
| LUX–YYC | Luxembourg – Calgary | 6 |
| PIK–SEA | Prestwick, South Ayrshire – Seattle | 5 |
| LUX–PIK | Luxembourg – Prestwick, South Ayrshire | 5 |
| LUX–SJU | Luxembourg – San Juan | 5 |
| JFK–NLU | New York – Mexico City | 5 |
| CVG–IND | Cincinnati / Covington – Indianapolis | 5 |
| ASB–STN | Ashgabat – London, Essex | 5 |
| DFW–VCP | Dallas-Fort Worth – Campinas | 4 |
| CGO–KMQ | Zhengzhou – Kanazawa | 4 |
| LUX–SGN | Luxembourg – Ho Chi Minh City | 4 |
| LUX–NRT | Luxembourg – Narita | 4 |
| GYD–KUL | Baku – Sepang | 4 |
| LUX–PEK | Luxembourg – Beijing | 3 |
| CGK–GYD | Jakarta – Baku | 3 |
| LGG–LUX | Grâce-Hollogne – Luxembourg | 3 |
| CGO–STN | Zhengzhou – London, Essex | 2 |
| CGK–LUX | Jakarta – Luxembourg | 2 |
| ATL–STN | Atlanta – London, Essex | 2 |
| ANC–BKK | Anchorage – Bangkok | 2 |
| ANC–KMQ | Anchorage – Kanazawa | 2 |
| LUX–TBS | Luxembourg – Tbilisi | 2 |
| HKG–NLU | Hong Kong – Mexico City | 2 |
| ARN–LAX | Stockholm – Los Angeles | 2 |
| GDL–HKGonce | Guadalajara – Hong Kong | 1 |
| LUX–MVDonce | Luxembourg – Ciudad de la Costa | 1 |