| DUS–PMI | Düsseldorf – Palma de Mallorca | 545 |
| FRA–PMI | Frankfurt am Main – Palma de Mallorca | 380 |
| HAM–PMI | Hamburg – Palma de Mallorca | 346 |
| FRA–JFK | Frankfurt am Main – New York | 320 |
| MUC–PMI | Munich – Palma de Mallorca | 310 |
| PMI–ZRH | Palma de Mallorca – Zurich | 288 |
| BCN–FRA | Barcelona – Frankfurt am Main | 253 |
| FRA–HER | Frankfurt am Main – Heraklion | 246 |
| DUS–HER | Düsseldorf – Heraklion | 241 |
| FRA–YYZ | Frankfurt am Main – Toronto | 240 |
| FRA–SFO | Frankfurt am Main – San Francisco | 234 |
| BER–FRA | Berlin – Frankfurt am Main | 228 |
| PMI–STR | Palma de Mallorca – Stuttgart | 222 |
| CAI–FRA | Cairo – Frankfurt am Main | 215 |
| FCO–FRA | Rome – Frankfurt am Main | 206 |
| FRA–LAX | Frankfurt am Main – Los Angeles | 201 |
| BKK–FRA | Bangkok – Frankfurt am Main | 199 |
| HER–ZRH | Heraklion – Zurich | 199 |
| FRA–TLV | Frankfurt am Main – Tel Aviv | 196 |
| HER–MUC | Heraklion – Munich | 186 |
| FRA–YVR | Frankfurt am Main – Vancouver | 174 |
| DUS–HRG | Düsseldorf – Hurghada | 172 |
| FMO–PMI | Greven – Palma de Mallorca | 151 |
| BOS–FRA | Boston – Frankfurt am Main | 147 |
| BER–HER | Berlin – Heraklion | 142 |
| BSL–PMI | Bâle / Mulhouse – Palma de Mallorca | 141 |
| LCA–ZRH | Larnaca – Zurich | 128 |
| FRA–HRG | Frankfurt am Main – Hurghada | 126 |
| FRA–VIE | Frankfurt am Main – Vienna | 126 |
| FRA–SEA | Frankfurt am Main – Seattle | 122 |
| HRG–MUC | Hurghada – Munich | 121 |
| DUS–RHO | Düsseldorf – Rhodes | 117 |
| HAM–VIE | Hamburg – Vienna | 117 |
| CGN–HER | Köln (Cologne) – Heraklion | 115 |
| FRA–KEF | Frankfurt am Main – Reykjavík | 114 |
| HER–STR | Heraklion – Stuttgart | 112 |
| FRA–LPA | Frankfurt am Main – Gran Canaria Island | 108 |
| DUS–LPA | Düsseldorf – Gran Canaria Island | 107 |
| DUS–FUE | Düsseldorf – El Matorral | 99 |
| FRA–FUE | Frankfurt am Main – El Matorral | 97 |
| DTM–PMI | Dortmund – Palma de Mallorca | 96 |
| FRA–RHO | Frankfurt am Main – Rhodes | 92 |
| FRA–TFS | Frankfurt am Main – Tenerife | 92 |
| EVN–FRA | Yerevan – Frankfurt am Main | 92 |
| FNC–FRA | Funchal – Frankfurt am Main | 90 |
| DUS–KGS | Düsseldorf – Kos Island | 89 |
| MUC–RHO | Munich – Rhodes | 87 |
| CFU–DUS | Kerkyra (Corfu) – Düsseldorf | 87 |
| CPT–FRA | Cape Town – Frankfurt am Main | 84 |
| IBZ–MUC | Ibiza (Eivissa) – Munich | 83 |
| FRA–YYC | Frankfurt am Main – Calgary | 82 |
| FRA–JNB | Frankfurt am Main – Johannesburg | 81 |
| HAM–HRG | Hamburg – Hurghada | 80 |
| MUC–OLB | Munich – Olbia (SS) | 78 |
| DUS–TFS | Düsseldorf – Tenerife | 77 |
| CUN–FRA | Cancún – Frankfurt am Main | 76 |
| KGS–ZRH | Kos Island – Zurich | 74 |
| RHO–ZRH | Rhodes – Zurich | 73 |
| CDG–FRA | Paris (Roissy-en-France, Val-d'Oise) – Frankfurt am Main | 70 |
| FRA–KGS | Frankfurt am Main – Kos Island | 66 |
| BER–RHO | Berlin – Rhodes | 66 |
| FRA–LAS | Frankfurt am Main – Las Vegas | 64 |
| BEY–DUS | Beirut – Düsseldorf | 64 |
| FRA–IBZ | Frankfurt am Main – Ibiza (Eivissa) | 64 |
| IBZ–ZRH | Ibiza (Eivissa) – Zurich | 62 |
| KGS–MUC | Kos Island – Munich | 61 |
| CHQ–FRA | Souda – Frankfurt am Main | 61 |
| FRA–SPU | Frankfurt am Main – Split | 60 |
| DUS–FNC | Düsseldorf – Funchal | 58 |
| FRA–PUJ | Frankfurt am Main – Punta Cana | 57 |
| CHQ–MUC | Souda – Munich | 56 |
| LPA–MUC | Gran Canaria Island – Munich | 56 |
| FRA–MBA | Frankfurt am Main – Mombasa | 54 |
| FUE–HAM | El Matorral – Hamburg | 54 |
| MUC–TFS | Munich – Tenerife | 53 |
| FRA–XRY | Frankfurt am Main – Jerez de la Frontera | 53 |
| BER–KGS | Berlin – Kos Island | 52 |
| DUS–OLB | Düsseldorf – Olbia (SS) | 52 |
| DUS–LCA | Düsseldorf – Larnaca | 52 |
| HAM–KGS | Hamburg – Kos Island | 51 |
| CFU–FRA | Kerkyra (Corfu) – Frankfurt am Main | 51 |
| BUD–FRA | Budapest – Frankfurt am Main | 50 |
| CFU–MUC | Kerkyra (Corfu) – Munich | 49 |
| DUS–XRY | Düsseldorf – Jerez de la Frontera | 48 |
| FRA–MRU | Frankfurt am Main – Plaine Magnien | 46 |
| ACE–FRA | San Bartolomé – Frankfurt am Main | 45 |
| FRA–OLB | Frankfurt am Main – Olbia (SS) | 45 |
| FUE–MUC | El Matorral – Munich | 44 |
| CHQ–DUS | Souda – Düsseldorf | 43 |
| FNC–MUC | Funchal – Munich | 43 |
| HAM–LPA | Hamburg – Gran Canaria Island | 38 |
| FRA–ZNZ | Frankfurt am Main – Zanzibar | 36 |
| FRA–MXP | Frankfurt am Main – Ferno (VA) | 35 |
| DUS–SMI | Düsseldorf – Samos Island | 34 |
| FRA–HAM | Frankfurt am Main – Hamburg | 30 |
| BER–DUS | Berlin – Düsseldorf | 30 |
| CDG–FNC | Paris (Roissy-en-France, Val-d'Oise) – Funchal | 29 |
| ACE–MUC | San Bartolomé – Munich | 29 |
| FRA–KLX | Frankfurt am Main – Kalamata | 27 |
| FRA–VCE | Frankfurt am Main – Venezia (VE) | 27 |
| DUS–SUF | Düsseldorf – Lamezia Terme (CZ) | 26 |
| FRA–LGW | Frankfurt am Main – London | 26 |
| FRA–PRG | Frankfurt am Main – Prague | 25 |
| ACE–DUS | San Bartolomé – Düsseldorf | 24 |
| DUS–PVK | Düsseldorf – Preveza | 21 |
| HAM–TFS | Hamburg – Tenerife | 21 |
| FRA–SEZ | Frankfurt am Main – Victoria | 21 |
| FKB–HER | Rheinmünster – Heraklion | 21 |
| MUC–SUF | Munich – Lamezia Terme (CZ) | 20 |
| MUC–ZTH | Munich – Zakynthos | 19 |
| DUS–ZTH | Düsseldorf – Zakynthos | 19 |
| FRA–SUF | Frankfurt am Main – Lamezia Terme (CZ) | 19 |
| HAM–ZTH | Hamburg – Zakynthos | 18 |
| FRA–MLE | Frankfurt am Main – Malé | 17 |
| FRA–ZTH | Frankfurt am Main – Zakynthos | 16 |
| FRA–PVK | Frankfurt am Main – Preveza | 16 |
| AGA–DUS | Agadir (Temsia) – Düsseldorf | 15 |
| FRA–KVA | Frankfurt am Main – Kavala | 15 |
| ANC–FRA | Anchorage – Frankfurt am Main | 14 |
| JSI–MUC | Skiathos – Munich | 13 |
