| LPA–MAD | Gran Canaria Island – Madrid | 867 |
| DEN–ORD | Denver – Chicago | 824 |
| MAD–TFN | Madrid – Tenerife | 750 |
| MAD–PMI | Madrid – Palma de Mallorca | 742 |
| FCO–MAD | Rome – Madrid | 739 |
| LIS–MAD | Lisbon – Madrid | 646 |
| BCN–MAD | Barcelona – Madrid | 478 |
| LHR–MAD | London – Madrid | 464 |
| BOG–MAD | Bogota – Madrid | 459 |
| BCN–IBZ | Barcelona – Ibiza (Eivissa) | 446 |
| EZE–MAD | Buenos Aires (Ezeiza) – Madrid | 419 |
| GIG–SCL | Rio De Janeiro – Santiago | 405 |
| MAD–MUC | Madrid – Munich | 377 |
| AMS–MAD | Amsterdam – Madrid | 373 |
| MAD–MXP | Madrid – Ferno (VA) | 368 |
| IBZ–MAD | Ibiza (Eivissa) – Madrid | 364 |
| MAD–OPO | Madrid – Porto | 359 |
| CDG–MAD | Paris (Roissy-en-France, Val-d'Oise) – Madrid | 354 |
| FRA–MAD | Frankfurt am Main – Madrid | 353 |
| MAD–MEX | Madrid – Mexico City | 351 |
| BRU–MAD | Zaventem – Madrid | 349 |
| GRU–MAD | São Paulo – Madrid | 344 |
| MAH–PMI | Mahón (Maó) – Palma de Mallorca | 333 |
| IBZ–PMI | Ibiza (Eivissa) – Palma de Mallorca | 328 |
| MAD–ORY | Madrid – Paris (Orly, Val-de-Marne) | 327 |
| GVA–MAD | Geneva – Madrid | 309 |
| LIM–MAD | Lima – Madrid | 305 |
| ATH–MAD | Spata-Artemida – Madrid | 300 |
| AGP–MLN | Málaga – Melilla | 274 |
| MAD–ZRH | Madrid – Zurich | 273 |
| LGW–MAD | London – Madrid | 272 |
| JFK–MAD | New York – Madrid | 269 |
| MAD–VCE | Madrid – Venezia (VE) | 256 |
| ACE–MAD | San Bartolomé – Madrid | 255 |
| LCG–MAD | Culleredo – Madrid | 252 |
| AGP–MAD | Málaga – Madrid | 239 |
| MAD–VGO | Madrid – Vigo | 225 |
| MAD–MIA | Madrid – Miami | 220 |
| MAD–SCL | Madrid – Santiago | 220 |
| DUS–MAD | Düsseldorf – Madrid | 210 |
| PMI–VLC | Palma de Mallorca – Valencia | 207 |
| MAD–OVD | Madrid – Ranón | 207 |
| MAD–RAK | Madrid – Marrakesh | 198 |
| BIO–MAD | Bilbao – Madrid | 197 |
| MAD–SDQ | Madrid – Santo Domingo | 196 |
| BOS–MAD | Boston – Madrid | 195 |
| MAD–MAH | Madrid – Mahón (Maó) | 190 |
| MAD–SVQ | Madrid – Seville | 183 |
| CMN–MAD | Casablanca – Madrid | 180 |
| MAD–VLC | Madrid – Valencia | 180 |
| MAD–MLN | Madrid – Melilla | 176 |
| MAD–OTP | Madrid – Otopeni | 175 |
| LYS–MAD | Colombier-Saugnieu, Rhône – Madrid | 173 |
| MAD–NCE | Madrid – Nice, Alpes-Maritimes | 172 |
| MAD–MRS | Madrid – Marignane, Bouches-du-Rhône | 171 |
| ASE–DFW | Aspen – Dallas-Fort Worth | 170 |
| CPH–MAD | Copenhagen – Madrid | 169 |
| DUB–MAD | Dublin – Madrid | 166 |
| ALC–MAD | Alicante – Madrid | 163 |
| FUE–MAD | El Matorral – Madrid | 161 |
| IBZ–VLC | Ibiza (Eivissa) – Valencia | 153 |
| MAD–VIE | Madrid – Vienna | 152 |
| MAD–TFS | Madrid – Tenerife | 147 |
| BLQ–MAD | Bologna – Madrid | 142 |
| CCS–MAD | Maiquetía – Madrid | 140 |
| BUD–MAD | Budapest – Madrid | 135 |
| LIN–MAD | Segrate (MI) – Madrid | 135 |
| MAD–NAP | Madrid – Napoli | 134 |
| CAI–MAD | Cairo – Madrid | 133 |
| MAD–PRG | Madrid – Prague | 133 |
| BER–MAD | Berlin – Madrid | 131 |
| BCN–BOS | Barcelona – Boston | 128 |
| FLR–MAD | Firenze (FI) – Madrid | 125 |
| MAD–TNG | Madrid – Tangier | 124 |
| IAD–MAD | Dulles – Madrid | 118 |
| GUA–SAL | Guatemala City – San Salvador (San Luis Talpa) | 117 |
| MAD–ORD | Madrid – Chicago | 112 |
| MAD–MVD | Madrid – Ciudad de la Costa | 109 |
| ALC–IBZ | Alicante – Ibiza (Eivissa) | 108 |
| EWR–MAD | Newark – Madrid | 105 |
| DFW–MAD | Dallas-Fort Worth – Madrid | 102 |
| MAD–YYZ | Madrid – Toronto | 101 |
| SVQ–VLC | Seville – Valencia | 101 |
| MAD–PTY | Madrid – Tocumen | 100 |
| LEI–MAD | Almería – Madrid | 99 |
| MAD–XRY | Madrid – Jerez de la Frontera | 96 |
| MAD–UIO | Madrid – Quito | 95 |
| LTN–MAD | Luton, Luton – Madrid | 94 |
| ARN–MAD | Stockholm – Madrid | 93 |
| MAD–MAN | Madrid – Manchester, Greater Manchester | 93 |
| MAD–SJU | Madrid – San Juan | 89 |
| EDI–MAD | Ingliston, Edinburgh – Madrid | 88 |
| AGP–VLC | Málaga – Valencia | 87 |
| MAD–SJO | Madrid – San José (Alajuela) | 87 |
| MAD–OSL | Madrid – Oslo (Gardermoen) | 86 |
| MAD–TLS | Madrid – Toulouse/Blagnac | 86 |
| MAD–SCQ | Madrid – Santiago de Compostela | 86 |
| HAM–MAD | Hamburg – Madrid | 83 |
| GRX–MAD | Granada – Madrid | 83 |
| DSS–MAD | Dakar – Madrid | 83 |
| GIG–MIA | Rio De Janeiro – Miami | 81 |
| GYE–MAD | Guayaquil – Madrid | 80 |
| BCN–MIA | Barcelona – Miami | 79 |
| MAD–MTY | Madrid – Monterrey | 79 |
| MAD–PNA | Madrid – Pamplona | 74 |
| BIO–VLC | Bilbao – Valencia | 74 |
| MAD–SDR | Madrid – Santander | 73 |
| MAD–SPC | Madrid – Sta Cruz de la Palma, La Palma Island | 72 |
| MAD–REC | Madrid – Recife | 71 |
| DBV–MAD | Dubrovnik – Madrid | 64 |
| FAO–MAD | Faro – Madrid | 62 |
| BCN–VLC | Barcelona – Valencia | 61 |
| MAD–NTE | Madrid – Nantes | 59 |
| MAD–TRN | Madrid – Caselle Torinese (TO) | 59 |
| BOD–MAD | Bordeaux – Madrid | 59 |
| CTA–MAD | Catania – Madrid | 58 |
| LEI–MLN | Almería – Melilla | 58 |
| MAH–VLC | Mahón (Maó) – Valencia | 58 |
| LEI–SVQ | Almería – Seville | 55 |
| GIG–MAD | Rio De Janeiro – Madrid | 51 |
