| FCO–MAD | Rome – Madrid | 739 |
| FCO–PMO | Rome – Palermo | 679 |
| CTA–FCO | Catania – Rome | 567 |
| BCN–FCO | Barcelona – Rome | 515 |
| FCO–TLV | Rome – Tel Aviv | 442 |
| FCO–JFK | Rome – New York | 428 |
| FCO–LHR | Rome – London | 384 |
| FCO–LIN | Rome – Segrate (MI) | 381 |
| CDG–FCO | Paris (Roissy-en-France, Val-d'Oise) – Rome | 378 |
| ATH–FCO | Spata-Artemida – Rome | 370 |
| FCO–MLA | Rome – Valletta | 240 |
| BRI–FCO | Bari – Rome | 240 |
| FCO–YYZ | Rome – Toronto | 234 |
| LCY–LIN | London – Segrate (MI) | 221 |
| CDG–LIN | Paris (Roissy-en-France, Val-d'Oise) – Segrate (MI) | 218 |
| AMS–LIN | Amsterdam – Segrate (MI) | 218 |
| CTA–LIN | Catania – Segrate (MI) | 217 |
| AMS–FCO | Amsterdam – Rome | 209 |
| FCO–FRA | Rome – Frankfurt am Main | 206 |
| AGP–FCO | Málaga – Rome | 201 |
| BDS–FCO | Brindisi – Rome | 200 |
| FCO–VLC | Rome – Valencia | 193 |
| CAI–FCO | Cairo – Rome | 192 |
| FCO–GRU | Rome – São Paulo | 191 |
| BRI–LIN | Bari – Segrate (MI) | 190 |
| LIN–PMO | Segrate (MI) – Palermo | 189 |
| BRU–FCO | Zaventem – Rome | 181 |
| FCO–GOA | Rome – Genova (GE) | 179 |
| FCO–IAD | Rome – Dulles | 176 |
| LIN–NAP | Segrate (MI) – Napoli | 173 |
| FCO–NCE | Rome – Nice, Alpes-Maritimes | 161 |
| FCO–ORD | Rome – Chicago | 160 |
| FCO–TRS | Rome – Ronchi dei Legionari/Trieste | 147 |
| FCO–TRN | Rome – Caselle Torinese (TO) | 146 |
| FCO–VCE | Rome – Venezia (VE) | 145 |
| DEL–FCO | New Delhi – Rome | 143 |
| BLQ–MAD | Bologna – Madrid | 142 |
| FCO–NAP | Rome – Napoli | 136 |
| FCO–MIA | Rome – Miami | 135 |
| FCO–TUN | Rome – Tunis | 134 |
| FCO–SUF | Rome – Lamezia Terme (CZ) | 133 |
| FCO–SAW | Rome – Pendik, Istanbul | 132 |
| EZE–FCO | Buenos Aires (Ezeiza) – Rome | 130 |
| FCO–FLR | Rome – Firenze (FI) | 123 |
| FCO–SFO | Rome – San Francisco | 118 |
| FCO–MUC | Rome – Munich | 114 |
| BOS–FCO | Boston – Rome | 110 |
| BLQ–FCO | Bologna – Rome | 108 |
| FCO–ZRH | Rome – Zurich | 106 |
| ALG–FCO | Algiers – Rome | 100 |
| CDG–FLR | Paris (Roissy-en-France, Val-d'Oise) – Firenze (FI) | 99 |
| FCO–TIA | Rome – Rinas | 97 |
| FCO–RUH | Rome – Riyadh | 93 |
| FCO–PMI | Rome – Palma de Mallorca | 92 |
| LIN–SUF | Segrate (MI) – Lamezia Terme (CZ) | 91 |
| FCO–GVA | Rome – Geneva | 91 |
| AHO–LIN | Alghero – Segrate (MI) | 90 |
| FCO–IBZ | Rome – Ibiza (Eivissa) | 87 |
| BRU–LIN | Zaventem – Segrate (MI) | 86 |
| LIN–REG | Segrate (MI) – Reggio Calabria | 85 |
| ALC–FCO | Alicante – Rome | 83 |
| CIY–FCO | Comiso – Rome | 82 |
| LIN–ORY | Segrate (MI) – Paris (Orly, Val-de-Marne) | 79 |
| FCO–MRS | Rome – Marignane, Bouches-du-Rhône | 72 |
| FCO–REG | Rome – Reggio Calabria | 69 |
| FCO–LAX | Rome – Los Angeles | 63 |
| EVN–FCO | Yerevan – Rome | 63 |
| BDS–LIN | Brindisi – Segrate (MI) | 63 |
| FCO–HND | Rome – Tokyo | 62 |
| FCO–GIG | Rome – Rio De Janeiro | 56 |
| CIY–LIN | Comiso – Segrate (MI) | 55 |
| LIN–MUC | Segrate (MI) – Munich | 53 |
| FCO–TPS | Rome – Trapani (TP) | 50 |
| HAM–LIN | Hamburg – Segrate (MI) | 49 |
| FCO–HAM | Rome – Hamburg | 43 |
| OLB–TRN | Olbia (SS) – Caselle Torinese (TO) | 43 |
| FCO–SSH | Rome – Sharm El Sheikh | 41 |
| FCO–IAH | Rome – Houston | 38 |
| CFU–FCO | Kerkyra (Corfu) – Rome | 33 |
| ACC–FCO | Accra – Rome | 33 |
| DSS–FCO | Dakar – Rome | 32 |
| BKK–FCO | Bangkok – Rome | 32 |
| FCO–LMP | Rome – Lampedusa | 31 |
| FCO–HER | Rome – Heraklion | 26 |
| FCO–GYD | Rome – Baku | 20 |
| EFL–FCO | Kefallinia Island – Rome | 19 |
| BTS–FCO | Bratislava – Rome | 17 |
| GOA–OLB | Genova (GE) – Olbia (SS) | 13 |
| FCO–ZTH | Rome – Zakynthos | 9 |
| FCO–MAH | Rome – Mahón (Maó) | 8 |
| FCO–PNL | Rome – Pantelleria (TP) | 6 |
| LIN–PNL | Segrate (MI) – Pantelleria (TP) | 5 |
| LIN–MAH | Segrate (MI) – Mahón (Maó) | 4 |
| BLQ–NAP | Bologna – Napoli | 4 |
| LIN–RLG | Segrate (MI) – Laage | 3 |
| EVN–PSA | Yerevan – Pisa (PI) | 3 |
| FCO–YEI | Rome – Yenişehir | 2 |
| HER–LINonce | Heraklion – Segrate (MI) | 1 |
| FCO–KULonce | Rome – Sepang | 1 |
| FCO–PSAonce | Rome – Pisa (PI) | 1 |