| BOM–MAA | Mumbai – Chennai | 647 |
| ATL–CLT | Atlanta – Charlotte | 528 |
| FRA–PVG | Frankfurt am Main – Shanghai (Pudong) | 397 |
| FRA–PMI | Frankfurt am Main – Palma de Mallorca | 380 |
| MAD–MUC | Madrid – Munich | 377 |
| FRA–MAD | Frankfurt am Main – Madrid | 353 |
| FRA–IST | Frankfurt am Main – Istanbul | 320 |
| FRA–JFK | Frankfurt am Main – New York | 320 |
| FRA–ORD | Frankfurt am Main – Chicago | 310 |
| MUC–PMI | Munich – Palma de Mallorca | 310 |
| FRA–LIS | Frankfurt am Main – Lisbon | 294 |
| ATH–MUC | Spata-Artemida – Munich | 287 |
| HYD–MAA | Hyderabad – Chennai | 264 |
| BCN–FRA | Barcelona – Frankfurt am Main | 253 |
| FRA–YYZ | Frankfurt am Main – Toronto | 240 |
| ATH–FRA | Spata-Artemida – Frankfurt am Main | 239 |
| FRA–ICN | Frankfurt am Main – Seoul | 235 |
| FRA–SFO | Frankfurt am Main – San Francisco | 234 |
| BER–FRA | Berlin – Frankfurt am Main | 228 |
| FRA–IAD | Frankfurt am Main – Dulles | 225 |
| LIS–MUC | Lisbon – Munich | 224 |
| IST–MUC | Istanbul – Munich | 224 |
| CAI–FRA | Cairo – Frankfurt am Main | 215 |
| FCO–FRA | Rome – Frankfurt am Main | 206 |
| FRA–LAX | Frankfurt am Main – Los Angeles | 201 |
| CPH–MUC | Copenhagen – Munich | 199 |
| MUC–TLV | Munich – Tel Aviv | 199 |
| FRA–TLV | Frankfurt am Main – Tel Aviv | 196 |
| BCN–MUC | Barcelona – Munich | 192 |
| HER–MUC | Heraklion – Munich | 186 |
| FRA–LHR | Frankfurt am Main – London | 184 |
| DEL–FRA | New Delhi – Frankfurt am Main | 183 |
| FRA–HND | Frankfurt am Main – Tokyo | 180 |
| HEL–MUC | Helsinki (Vantaa) – Munich | 180 |
| FRA–WAW | Frankfurt am Main – Warsaw | 177 |
| ATL–FRA | Atlanta – Frankfurt am Main | 175 |
| FRA–YVR | Frankfurt am Main – Vancouver | 174 |
| LHR–MUC | London – Munich | 171 |
| MUC–ORD | Munich – Chicago | 170 |
| HKG–IST | Hong Kong – Istanbul | 170 |
| MLA–MUC | Valletta – Munich | 168 |
| ARN–FRA | Stockholm – Frankfurt am Main | 167 |
| CPH–FRA | Copenhagen – Frankfurt am Main | 166 |
| DUB–FRA | Dublin – Frankfurt am Main | 162 |
| CPH–HAM | Copenhagen – Hamburg | 160 |
| FRA–SIN | Frankfurt am Main – Singapore | 154 |
| FRA–GRU | Frankfurt am Main – São Paulo | 154 |
| FRA–PEK | Frankfurt am Main – Beijing | 153 |
| FRA–HKG | Frankfurt am Main – Hong Kong | 149 |
| ARN–MUC | Stockholm – Munich | 148 |
| FRA–TUN | Frankfurt am Main – Tunis | 147 |
| BOS–FRA | Boston – Frankfurt am Main | 147 |
| FRA–OSL | Frankfurt am Main – Oslo (Gardermoen) | 144 |
| CDG–MUC | Paris (Roissy-en-France, Val-d'Oise) – Munich | 141 |
| HAM–MUC | Hamburg – Munich | 136 |
| DFW–FRA | Dallas-Fort Worth – Frankfurt am Main | 129 |
| BOM–FRA | Mumbai – Frankfurt am Main | 127 |
| FRA–YUL | Frankfurt am Main – Montréal | 127 |
| MUC–SIN | Munich – Singapore | 127 |
| AGP–MUC | Málaga – Munich | 126 |
| FRA–IAH | Frankfurt am Main – Houston | 124 |
| FRA–OPO | Frankfurt am Main – Porto | 124 |
| HND–MUC | Tokyo – Munich | 123 |
| BKK–MUC | Bangkok – Munich | 123 |
| FRA–TLL | Frankfurt am Main – Tallinn | 122 |
| FRA–SEA | Frankfurt am Main – Seattle | 122 |
| MUC–SFO | Munich – San Francisco | 120 |
| DEN–MUC | Denver – Munich | 120 |
| FRA–VNO | Frankfurt am Main – Vilnius | 119 |
| MUC–YYZ | Munich – Toronto | 118 |
| DEN–FRA | Denver – Frankfurt am Main | 117 |
| FRA–NRT | Frankfurt am Main – Narita | 117 |
| DTW–FRA | Detroit – Frankfurt am Main | 116 |
| MUC–PEK | Munich – Beijing | 115 |
| FRA–MLA | Frankfurt am Main – Valletta | 115 |
| FRA–KEF | Frankfurt am Main – Reykjavík | 114 |
| EWR–MUC | Newark – Munich | 114 |
| FCO–MUC | Rome – Munich | 114 |
| AGP–FRA | Málaga – Frankfurt am Main | 114 |
| MUC–SKG | Munich – Thessaloniki | 114 |
| BIO–FRA | Bilbao – Frankfurt am Main | 114 |
| IAD–MUC | Dulles – Munich | 113 |
| FRA–LIN | Frankfurt am Main – Segrate (MI) | 112 |
| EDI–FRA | Ingliston, Edinburgh – Frankfurt am Main | 111 |
| CLT–MUC | Charlotte – Munich | 110 |
| CTA–MUC | Catania – Munich | 110 |
| FRA–RIX | Frankfurt am Main – Riga | 109 |
| FRA–SKG | Frankfurt am Main – Thessaloniki | 109 |
| ABV–PHC | Abuja – Port Harcourt | 108 |
| EWR–FRA | Newark – Frankfurt am Main | 107 |
| FRA–OTP | Frankfurt am Main – Otopeni | 104 |
| FRA–MAN | Frankfurt am Main – Manchester, Greater Manchester | 103 |
| MUC–OSL | Munich – Oslo (Gardermoen) | 102 |
| BGO–FRA | Bergen – Frankfurt am Main | 99 |
| MUC–OTP | Munich – Otopeni | 99 |
| MUC–WAW | Munich – Warsaw | 99 |
| BLL–FRA | Billund – Frankfurt am Main | 98 |
| FRA–VLC | Frankfurt am Main – Valencia | 97 |
| FRA–NAP | Frankfurt am Main – Napoli | 96 |
| CMN–FRA | Casablanca – Frankfurt am Main | 93 |
| ALG–FRA | Algiers – Frankfurt am Main | 92 |
| MUC–PVG | Munich – Shanghai (Pudong) | 92 |
| EVN–FRA | Yerevan – Frankfurt am Main | 92 |
| CAI–MUC | Cairo – Munich | 91 |
| BER–MUC | Berlin – Munich | 91 |
| DUB–MUC | Dublin – Munich | 90 |
| ADB–MUC | Gaziemir – Munich | 90 |
| FRA–GOT | Frankfurt am Main – Göteborg | 89 |
| BIO–MUC | Bilbao – Munich | 88 |
| MUC–RHO | Munich – Rhodes | 87 |
| CPT–FRA | Cape Town – Frankfurt am Main | 84 |
| FRA–LCA | Frankfurt am Main – Larnaca | 84 |
| FRA–TIA | Frankfurt am Main – Rinas | 82 |
| FRA–JNB | Frankfurt am Main – Johannesburg | 81 |
| MUC–PMO | Munich – Palermo | 80 |
| FRA–NQZ | Frankfurt am Main – Astana | 79 |
| FRA–ZAG | Frankfurt am Main – Velika Gorica | 79 |
| GOT–MUC | Göteborg – Munich | 78 |
| EDI–MUC | Ingliston, Edinburgh – Munich | 78 |
| MUC–OLB | Munich – Olbia (SS) | 78 |
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