| ATL–DCA | Atlanta – Washington | 811 |
| ATL–PHL | Atlanta – Philadelphia | 728 |
| BNA–DCA | Nashville – Washington | 642 |
| DFW–IAH | Dallas-Fort Worth – Houston | 625 |
| CLT–DFW | Charlotte – Dallas-Fort Worth | 570 |
| ATL–CLT | Atlanta – Charlotte | 528 |
| AUS–DFW | Austin – Dallas-Fort Worth | 486 |
| CLT–IAD | Charlotte – Dulles | 485 |
| CLT–PHL | Charlotte – Philadelphia | 467 |
| DFW–MAF | Dallas-Fort Worth – Midland | 462 |
| DCA–IAH | Washington – Houston | 457 |
| CLT–MDT | Charlotte – Harrisburg | 417 |
| DFW–XNA | Dallas-Fort Worth – Fayetteville/Springdale/Rogers | 412 |
| BNA–PHL | Nashville – Philadelphia | 407 |
| DFW–SDF | Dallas-Fort Worth – Louisville | 394 |
| DFW–LIT | Dallas-Fort Worth – Little Rock | 390 |
| DCA–RDU | Washington – Raleigh/Durham | 384 |
| DCA–MSP | Washington – Minneapolis | 378 |
| DCA–DFW | Washington – Dallas-Fort Worth | 377 |
| BHM–DFW | Birmingham – Dallas-Fort Worth | 368 |
| DFW–MEM | Dallas-Fort Worth – Memphis | 363 |
| CLT–ROA | Charlotte – Roanoke | 357 |
| DCA–IND | Washington – Indianapolis | 357 |
| CLT–TYS | Charlotte – Knoxville/Maryville | 356 |
| CLT–DCA | Charlotte – Washington | 355 |
| CVG–PHL | Cincinnati / Covington – Philadelphia | 355 |
| DFW–HSV | Dallas-Fort Worth – Huntsville | 329 |
| DCA–STL | Washington – St Louis | 326 |
| CLT–SAV | Charlotte – Savannah | 325 |
| DFW–ICT | Dallas-Fort Worth – Wichita | 325 |
| PHL–RDU | Philadelphia – Raleigh/Durham | 324 |
| DTW–PHL | Detroit – Philadelphia | 322 |
| BNA–CLT | Nashville – Charlotte | 321 |
| CLT–DAY | Charlotte – Dayton | 316 |
| CHO–CLT | Charlottesville – Charlotte | 313 |
| CHA–CLT | Chattanooga – Charlotte | 311 |
| CLT–ILM | Charlotte – Wilmington | 309 |
| BHM–CLT | Birmingham – Charlotte | 307 |
| DFW–STL | Dallas-Fort Worth – St Louis | 303 |
| AVL–CLT | Asheville – Charlotte | 300 |
| PHL–YYZ | Philadelphia – Toronto | 299 |
| DFW–HOU | Dallas-Fort Worth – Houston | 296 |
| DFW–MCI | Dallas-Fort Worth – Kansas City | 295 |
| DCA–DTW | Washington – Detroit | 293 |
| BTR–DFW | Baton Rouge – Dallas-Fort Worth | 291 |
| IND–PHL | Indianapolis – Philadelphia | 291 |
| DCA–PVD | Washington – Providence/Warwick | 284 |
| MSP–PHL | Minneapolis – Philadelphia | 280 |
| CLT–SDF | Charlotte – Louisville | 274 |
| CAE–CLT | Columbia – Charlotte | 269 |
| CLT–RIC | Charlotte – Richmond | 267 |
| DFW–JAN | Dallas-Fort Worth – Jackson | 266 |
| CVG–DCA | Cincinnati / Covington – Washington | 265 |
| CLT–YYZ | Charlotte – Toronto | 265 |
| DAY–DFW | Dayton – Dallas-Fort Worth | 263 |
| CLT–GSO | Charlotte – Greensboro | 263 |
| DFW–SHV | Dallas-Fort Worth – Shreveport | 261 |
| DCA–MCI | Washington – Kansas City | 260 |
| CMH–DCA | Columbus – Washington | 253 |
| CLT–ORF | Charlotte – Norfolk | 253 |
| CLT–HSV | Charlotte – Huntsville | 251 |
| JAX–PHL | Jacksonville – Philadelphia | 249 |
| CHS–CLT | Charleston – Charlotte | 249 |
| PHL–SDF | Philadelphia – Louisville | 247 |
| PHL–YUL | Philadelphia – Montréal | 245 |
| CLT–GSP | Charlotte – Greenville/Greer/Spartanburg | 243 |
| ORF–PHL | Norfolk – Philadelphia | 243 |
| CLT–HPN | Charlotte – White Plains | 239 |
| CLT–TRI | Charlotte – Blountville | 238 |
| CVG–DFW | Cincinnati / Covington – Dallas-Fort Worth | 238 |
| CLT–RDU | Charlotte – Raleigh/Durham | 237 |
| DFW–TYS | Dallas-Fort Worth – Knoxville/Maryville | 235 |
| CHS–DCA | Charleston – Washington | 232 |
| CLT–SFO | Charlotte – San Francisco | 230 |
| CAK–CLT | Akron – Charlotte | 230 |
| CLT–LEX | Charlotte – Lexington | 230 |
| DFW–LFT | Dallas-Fort Worth – Lafayette | 227 |
| PHL–RIC | Philadelphia – Richmond | 225 |
| CLT–CVG | Charlotte – Cincinnati / Covington | 223 |
| PHL–TYS | Philadelphia – Knoxville/Maryville | 223 |
| MHT–PHL | Manchester – Philadelphia | 221 |
| PHL–PVD | Philadelphia – Providence/Warwick | 221 |
| AGS–CLT | Augusta – Charlotte | 216 |
| CLT–MYR | Charlotte – Myrtle Beach | 216 |
| PHL–STL | Philadelphia – St Louis | 214 |
| CLE–CLT | Cleveland – Charlotte | 213 |
| CLT–EWN | Charlotte – New Bern | 213 |
| DCA–YYZ | Washington – Toronto | 212 |
| CMH–PHL | Columbus – Philadelphia | 210 |
| GSO–PHL | Greensboro – Philadelphia | 209 |
| MKE–PHL | Milwaukee – Philadelphia | 208 |
| CLT–MEM | Charlotte – Memphis | 207 |
| BHM–DCA | Birmingham – Washington | 207 |
| MYR–PHL | Myrtle Beach – Philadelphia | 205 |
| DFW–LEX | Dallas-Fort Worth – Lexington | 205 |
| DFW–PNS | Dallas-Fort Worth – Pensacola | 204 |
| DFW–GRK | Dallas-Fort Worth – Fort Cavazos | 200 |
| DCA–SAV | Washington – Savannah | 200 |
| DCA–MKE | Washington – Milwaukee | 200 |
| DCA–HSV | Washington – Huntsville | 200 |
| CLT–XNA | Charlotte – Fayetteville/Springdale/Rogers | 200 |
| CLT–MHT | Charlotte – Manchester | 199 |
| MEM–PHL | Memphis – Philadelphia | 198 |
| PHL–PIT | Philadelphia – Pittsburgh | 198 |
| CLT–DAB | Charlotte – Daytona Beach | 197 |
| CLT–TLH | Charlotte – Tallahassee | 196 |
| CLT–LIT | Charlotte – Little Rock | 196 |
| DFW–SBN | Dallas-Fort Worth – South Bend | 196 |
| DAY–DCA | Dayton – Washington | 193 |
| PHL–PWM | Philadelphia – Portland | 192 |
| DCA–MSY | Washington – New Orleans | 188 |
| DCA–MSN | Washington – Madison | 187 |
| CLT–PIT | Charlotte – Pittsburgh | 184 |
| DFW–DSM | Dallas-Fort Worth – Des Moines | 183 |
| CLE–DCA | Cleveland – Washington | 183 |
| DFW–MGM | Dallas-Fort Worth – Montgomery | 183 |
| CLE–PHL | Cleveland – Philadelphia | 182 |
| CLT–OAJ | Charlotte – Richlands | 181 |
| ALB–DCA | Albany – Washington | 177 |
| DFW–MOB | Dallas-Fort Worth – Mobile | 176 |