| ATH–TLV | Spata-Artemida – Tel Aviv | 682 |
| ATH–JTR | Spata-Artemida – Santorini Island | 579 |
| ATH–LCA | Spata-Artemida – Larnaca | 561 |
| ATH–SKG | Spata-Artemida – Thessaloniki | 485 |
| ATH–HER | Spata-Artemida – Heraklion | 414 |
| ATH–FCO | Spata-Artemida – Rome | 370 |
| ATH–PAS | Spata-Artemida – Paros | 355 |
| ATH–CDG | Spata-Artemida – Paris (Roissy-en-France, Val-d'Oise) | 316 |
| ATH–IST | Spata-Artemida – Istanbul | 303 |
| ATH–MAD | Spata-Artemida – Madrid | 300 |
| ATH–JNX | Spata-Artemida – Naxos | 295 |
| ATH–CHQ | Spata-Artemida – Souda | 290 |
| ATH–MUC | Spata-Artemida – Munich | 287 |
| ATH–JMK | Spata-Artemida – Mykonos | 261 |
| ATH–RHO | Spata-Artemida – Rhodes | 259 |
| AMS–ATH | Amsterdam – Spata-Artemida | 251 |
| ATH–FRA | Spata-Artemida – Frankfurt am Main | 239 |
| ATH–KGS | Spata-Artemida – Kos Island | 223 |
| ATH–MXP | Spata-Artemida – Ferno (VA) | 218 |
| ATH–JKH | Spata-Artemida – Chios Island | 196 |
| ATH–MJT | Spata-Artemida – Mytilene | 193 |
| ATH–CFU | Spata-Artemida – Kerkyra (Corfu) | 186 |
| ATH–BRU | Spata-Artemida – Zaventem | 174 |
| ATH–MLO | Spata-Artemida – Milos Island | 172 |
| ATH–VIE | Spata-Artemida – Vienna | 163 |
| ATH–AXD | Spata-Artemida – Alexandroupolis | 162 |
| ATH–LGW | Spata-Artemida – London | 160 |
| ATH–WAW | Spata-Artemida – Warsaw | 155 |
| ATH–BER | Spata-Artemida – Berlin | 142 |
| ATH–EFL | Spata-Artemida – Kefallinia Island | 142 |
| ATH–LIS | Spata-Artemida – Lisbon | 141 |
| HER–SKG | Heraklion – Thessaloniki | 128 |
| ATH–TIA | Spata-Artemida – Rinas | 127 |
| ATH–DUS | Spata-Artemida – Düsseldorf | 118 |
| LCA–SKG | Larnaca – Thessaloniki | 118 |
| ATH–SMI | Spata-Artemida – Samos Island | 117 |
| DUS–SKG | Düsseldorf – Thessaloniki | 107 |
| BRU–HER | Zaventem – Heraklion | 107 |
| AMS–ZTH | Amsterdam – Zakynthos | 100 |
| ATH–ZTH | Spata-Artemida – Zakynthos | 91 |
| ATH–PRG | Spata-Artemida – Prague | 83 |
| ATH–LYS | Spata-Artemida – Colombier-Saugnieu, Rhône | 82 |
| ATH–JSI | Spata-Artemida – Skiathos | 80 |
| CDG–HER | Paris (Roissy-en-France, Val-d'Oise) – Heraklion | 79 |
| ATH–SOF | Spata-Artemida – Sofia | 78 |
| ATH–LXS | Spata-Artemida – Limnos Island | 76 |
| HER–LYS | Heraklion – Colombier-Saugnieu, Rhône | 75 |
| HER–NTE | Heraklion – Nantes | 74 |
| HER–RMO | Heraklion – Chişinău | 74 |
| BLL–CHQ | Billund – Souda | 70 |
| RHO–SKG | Rhodes – Thessaloniki | 70 |
| ATH–TBS | Spata-Artemida – Tbilisi | 68 |
| ATH–HAM | Spata-Artemida – Hamburg | 66 |
| CPH–RHO | Copenhagen – Rhodes | 65 |
| MJT–SKG | Mytilene – Thessaloniki | 61 |
| AOK–ATH | Karpathos Island – Spata-Artemida | 60 |
| ATH–JIK | Spata-Artemida – Ikaria Island | 60 |
| HER–RHO | Heraklion – Rhodes | 53 |
| HER–MRS | Heraklion – Marignane, Bouches-du-Rhône | 46 |
| BLL–RHO | Billund – Rhodes | 46 |
| JMK–SKG | Mykonos – Thessaloniki | 46 |
| ATH–EVN | Spata-Artemida – Yerevan | 40 |
| PAS–SKG | Paros – Thessaloniki | 38 |
| HER–LCA | Heraklion – Larnaca | 38 |
| ATH–JTY | Spata-Artemida – Astypalaia Island | 32 |
| HER–TIA | Heraklion – Rinas | 30 |
| JKH–SKG | Chios Island – Thessaloniki | 30 |
| SKG–SMI | Thessaloniki – Samos Island | 28 |
| CPH–HER | Copenhagen – Heraklion | 28 |
| ATH–KIT | Spata-Artemida – Kithira Island | 26 |
| BRU–ZTH | Zaventem – Zakynthos | 26 |
| ATH–RAK | Spata-Artemida – Marrakesh | 26 |
| HER–LIL | Heraklion – Lesquin | 23 |
| BEG–HER | Belgrade – Heraklion | 17 |
| BLL–ZTH | Billund – Zakynthos | 14 |
| ATH–JKL | Spata-Artemida – Kalymnos Island | 12 |
| LXS–MJT | Limnos Island – Mytilene | 11 |
| GHV–HER | Brașov (Ghimbav) – Heraklion | 11 |
| HER–JTR | Heraklion – Santorini Island | 11 |
| AXD–JSH | Alexandroupolis – Crete Island | 11 |
| JSH–PVK | Crete Island – Preveza | 11 |
| ATH–JSY | Spata-Artemida – Syros Island | 11 |
| HER–KIV | Heraklion – KIV | 10 |
| SKG–SKU | Thessaloniki – Skiros Island | 10 |
| HER–VOL | Heraklion – Nea Anchialos | 10 |
| HER–SBZ | Heraklion – Sibiu | 8 |
| CFU–PVK | Kerkyra (Corfu) – Preveza | 7 |
| JKL–LRS | Kalymnos Island – Leros Island | 6 |
| KIV–RMO | KIV – Chişinău | 6 |
| HER–TBS | Heraklion – Tbilisi | 6 |
| JTY–LRS | Astypalaia Island – Leros Island | 6 |
| EFL–PVK | Kefallinia Island – Preveza | 6 |
| ATH–KZI | Spata-Artemida – Kozani | 5 |
| HER–SCV | Heraklion – Suceava | 5 |
| RHO–SMI | Rhodes – Samos Island | 4 |
| EFL–ZTH | Kefallinia Island – Zakynthos | 3 |
| JKH–MJT | Chios Island – Mytilene | 3 |
| IAS–RHO | Iaşi – Rhodes | 2 |
| HER–TGM | Heraklion – Recea | 2 |
| EVN–HER | Yerevan – Heraklion | 2 |
| JKH–SMI | Chios Island – Samos Island | 2 |
| JKL–KGSonce | Kalymnos Island – Kos Island | 1 |
| KGS–RHOonce | Kos Island – Rhodes | 1 |
| ATH–KSOonce | Spata-Artemida – Argos Orestiko | 1 |
| CDG–RHOonce | Paris (Roissy-en-France, Val-d'Oise) – Rhodes | 1 |