| LIS–MAD | Lisbon – Madrid | 646 |
| CPH–OSL | Copenhagen – Oslo (Gardermoen) | 632 |
| FNC–LIS | Funchal – Lisbon | 544 |
| BCN–LIS | Barcelona – Lisbon | 505 |
| LIS–ORY | Lisbon – Paris (Orly, Val-de-Marne) | 504 |
| LHR–LIS | London – Lisbon | 454 |
| AMS–LIS | Amsterdam – Lisbon | 420 |
| CWB–GIG | Curitiba – Rio De Janeiro | 386 |
| LIS–PDL | Lisbon – Ponta Delgada | 367 |
| BSB–GIG | Brasília – Rio De Janeiro | 343 |
| FCO–LIS | Rome – Lisbon | 333 |
| LIS–OPO | Lisbon – Porto | 329 |
| OPO–ORY | Porto – Paris (Orly, Val-de-Marne) | 310 |
| GRU–LIS | São Paulo – Lisbon | 306 |
| FRA–LIS | Frankfurt am Main – Lisbon | 294 |
| FNC–OPO | Funchal – Porto | 287 |
| GVA–OPO | Geneva – Porto | 276 |
| LIS–ZRH | Lisbon – Zurich | 266 |
| GVA–LIS | Geneva – Lisbon | 252 |
| BRU–LIS | Zaventem – Lisbon | 245 |
| LIS–MXP | Lisbon – Ferno (VA) | 236 |
| LIS–MUC | Lisbon – Munich | 224 |
| LGW–OPO | London – Porto | 214 |
| DUB–LIS | Dublin – Lisbon | 204 |
| LGW–LIS | London – Lisbon | 188 |
| LIS–YYZ | Lisbon – Toronto | 182 |
| BER–LIS | Berlin – Lisbon | 166 |
| OPO–ZRH | Porto – Zurich | 162 |
| IAD–LIS | Dulles – Lisbon | 159 |
| BOS–LIS | Boston – Lisbon | 153 |
| EWR–LIS | Newark – Lisbon | 151 |
| LIS–NBJ | Lisbon – Luanda (Ícolo e Bengo) | 150 |
| LIS–MAN | Lisbon – Manchester, Greater Manchester | 148 |
| LIS–TER | Lisbon – Praia da Vitória | 144 |
| ATH–LIS | Spata-Artemida – Lisbon | 141 |
| GIG–LIS | Rio De Janeiro – Lisbon | 137 |
| LIS–RAK | Lisbon – Marrakesh | 136 |
| LIS–YUL | Lisbon – Montréal | 134 |
| CPH–LIS | Copenhagen – Lisbon | 133 |
| EWR–OPO | Newark – Porto | 131 |
| LIS–LYS | Lisbon – Colombier-Saugnieu, Rhône | 131 |
| LIS–RAI | Lisbon – Praia | 130 |
| LIS–NCE | Lisbon – Nice, Alpes-Maritimes | 126 |
| LIS–LUX | Lisbon – Luxembourg | 125 |
| DUS–LIS | Düsseldorf – Lisbon | 124 |
| LIS–MRS | Lisbon – Marignane, Bouches-du-Rhône | 122 |
| OPO–PDL | Porto – Ponta Delgada | 121 |
| HAM–LIS | Hamburg – Lisbon | 120 |
| LIS–SVQ | Lisbon – Seville | 115 |
| LIS–WAW | Lisbon – Warsaw | 115 |
| JFK–LIS | New York – Lisbon | 112 |
| BEL–MAO | Belém – Manaus | 112 |
| LIS–VLC | Lisbon – Valencia | 109 |
| CMN–LIS | Casablanca – Lisbon | 106 |
| AGP–LIS | Málaga – Lisbon | 106 |
| LIS–SID | Lisbon – Espargos | 99 |
| LIS–VCE | Lisbon – Venezia (VE) | 99 |
| LIS–PMI | Lisbon – Palma de Mallorca | 95 |
| FAO–LIS | Faro – Lisbon | 93 |
| LIS–TLS | Lisbon – Toulouse/Blagnac | 93 |
| LIS–VIE | Lisbon – Vienna | 92 |
| CPH–OPO | Copenhagen – Porto | 86 |
| LIS–MIA | Lisbon – Miami | 84 |
| FOR–LIS | Fortaleza – Lisbon | 81 |
| LIS–PRG | Lisbon – Prague | 79 |
| BLQ–LIS | Bologna – Lisbon | 79 |
| LIS–VXE | Lisbon – São Pedro | 76 |
| OPO–TER | Porto – Praia da Vitória | 75 |
| LIS–OSL | Lisbon – Oslo (Gardermoen) | 74 |
| LIS–REC | Lisbon – Recife | 74 |
| LIS–NAP | Lisbon – Napoli | 73 |
| MUC–OPO | Munich – Porto | 73 |
| ARN–LIS | Stockholm – Lisbon | 66 |
| ALC–LIS | Alicante – Lisbon | 65 |
| BIO–LIS | Bilbao – Lisbon | 64 |
| FLR–LIS | Firenze (FI) – Lisbon | 60 |
| CNF–LIS | Belo Horizonte – Lisbon | 55 |
| LIS–PXO | Lisbon – Vila Baleira | 53 |
| IBZ–LIS | Ibiza (Eivissa) – Lisbon | 52 |
| BSB–LIS | Brasília – Lisbon | 51 |
| LIS–SSA | Lisbon – Salvador | 51 |
| OPO–SID | Porto – Espargos | 49 |
| LIS–MAH | Lisbon – Mahón (Maó) | 49 |
| LIS–NAT | Lisbon – Natal | 47 |
| BEL–LIS | Belém – Lisbon | 42 |
| DSS–LIS | Dakar – Lisbon | 41 |
| BOS–OPO | Boston – Porto | 41 |
| LIS–SFO | Lisbon – San Francisco | 40 |
| LIS–ORD | Lisbon – Chicago | 38 |
| LIS–POA | Lisbon – Porto Alegre | 37 |
| LAX–LIS | Los Angeles – Lisbon | 34 |
| FLN–LIS | Florianópolis – Lisbon | 33 |
| OPO–RAI | Porto – Praia | 31 |
| LIS–OXB | Lisbon – Bissau | 29 |
| BVC–LIS | Rabil – Lisbon | 27 |
| LIS–MPM | Lisbon – Maputo | 27 |
| LIS–TMS | Lisbon – São Tomé | 25 |
| LIS–TFS | Lisbon – Tenerife | 25 |
| GRU–OPO | São Paulo – Porto | 23 |
| BVC–OPO | Rabil – Porto | 22 |
| LIS–LPA | Lisbon – Gran Canaria Island | 20 |
| FAO–FNC | Faro – Funchal | 19 |
| GIG–OPO | Rio De Janeiro – Porto | 18 |
| DJE–LIS | Mellita – Lisbon | 17 |
| ACC–LIS | Accra – Lisbon | 17 |
| LIS–SMA | Lisbon – Vila do Porto | 14 |
| CWB–LIS | Curitiba – Lisbon | 13 |
| NBJ–OPO | Luanda (Ícolo e Bengo) – Porto | 11 |
| LIS–VLN | Lisbon – Valencia | 10 |
| ACC–TMS | Accra – São Tomé | 9 |
| LIS–OUD | Lisbon – Ahl Angad | 6 |
| FLR–VLC | Firenze (FI) – Valencia | 6 |
| MCZ–NAT | Maceió – Natal | 5 |
| DSS–OPO | Dakar – Porto | 3 |
| PTP–VLN | Pointe-à-Pitre – Valencia | 3 |
| SFO–TER | San Francisco – Praia da Vitória | 3 |
| LIS–PTP | Lisbon – Pointe-à-Pitre | 3 |
| AVR–LIS | Amravati – Lisbon | 2 |
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