| LAX–SFO | Los Angeles – San Francisco | 1,360 |
| LGA–ORD | New York – Chicago | 1,357 |
| LAX–SEA | Los Angeles – Seattle | 1,252 |
| LAX–ORD | Los Angeles – Chicago | 1,154 |
| BOS–ORD | Boston – Chicago | 1,101 |
| DFW–ORD | Dallas-Fort Worth – Chicago | 1,041 |
| DCA–ORD | Washington – Chicago | 978 |
| SAN–SFO | San Diego – San Francisco | 934 |
| DEN–PHX | Denver – Phoenix | 896 |
| LAX–PHX | Los Angeles – Phoenix | 895 |
| ORD–SFO | Chicago – San Francisco | 888 |
| BKK–HKG | Bangkok – Hong Kong | 883 |
| DEN–LAX | Denver – Los Angeles | 876 |
| LAS–LAX | Las Vegas – Los Angeles | 869 |
| ORD–SEA | Chicago – Seattle | 847 |
| DEN–SLC | Denver – Salt Lake City | 842 |
| ATL–ORD | Atlanta – Chicago | 833 |
| ORD–YYZ | Chicago – Toronto | 830 |
| DEN–ORD | Denver – Chicago | 824 |
| HNL–LAX | Honolulu, Oahu – Los Angeles | 822 |
| LAX–SMF | Los Angeles – Sacramento | 800 |
| BOS–LAX | Boston – Los Angeles | 799 |
| SFO–SNA | San Francisco – Santa Ana | 777 |
| DEN–SEA | Denver – Seattle | 776 |
| SEA–SFO | Seattle – San Francisco | 769 |
| YOW–YYZ | Ottawa – Toronto | 764 |
| BOS–SFO | Boston – San Francisco | 745 |
| ANC–ORD | Anchorage – Chicago | 739 |
| ORD–PHX | Chicago – Phoenix | 739 |
| ATL–LAX | Atlanta – Los Angeles | 736 |
| IAH–ORD | Houston – Chicago | 733 |
| BNA–ORD | Nashville – Chicago | 731 |
| DEN–LAS | Denver – Las Vegas | 727 |
| DTW–ORD | Detroit – Chicago | 727 |
| ORD–PHL | Chicago – Philadelphia | 719 |
| MSP–ORD | Minneapolis – Chicago | 710 |
| CLT–ORD | Charlotte – Chicago | 706 |
| DEN–SAN | Denver – San Diego | 706 |
| EWR–ORD | Newark – Chicago | 700 |
| DEN–MSP | Denver – Minneapolis | 695 |
| EWR–LAX | Newark – Los Angeles | 676 |
| CMH–ORD | Columbus – Chicago | 673 |
| LAS–SEA | Las Vegas – Seattle | 669 |
| DFW–SFO | Dallas-Fort Worth – San Francisco | 668 |
| ATL–DEN | Atlanta – Denver | 663 |
| DEN–DFW | Denver – Dallas-Fort Worth | 653 |
| ATL–EWR | Atlanta – Newark | 645 |
| LAS–SFO | Las Vegas – San Francisco | 640 |
| CVG–ORD | Cincinnati / Covington – Chicago | 628 |
| MCI–ORD | Kansas City – Chicago | 625 |
| DFW–IAH | Dallas-Fort Worth – Houston | 625 |
| ATL–IAH | Atlanta – Houston | 625 |
| AUS–DEN | Austin – Denver | 622 |
| ORD–TVC | Chicago – Traverse City | 616 |
| IND–ORD | Indianapolis – Chicago | 614 |
| LAS–ORD | Las Vegas – Chicago | 612 |
| DEN–SFO | Denver – San Francisco | 610 |
| LAX–PVG | Los Angeles – Shanghai (Pudong) | 606 |
| MCO–ORD | Orlando – Chicago | 596 |
| DFW–MCO | Dallas-Fort Worth – Orlando | 590 |
| CLT–EWR | Charlotte – Newark | 572 |
| PHX–SFO | Phoenix – San Francisco | 571 |
| CLT–DFW | Charlotte – Dallas-Fort Worth | 570 |
| DEN–LGA | Denver – New York | 570 |
| DEN–MCO | Denver – Orlando | 568 |
| EWR–SFO | Newark – San Francisco | 564 |
| DEN–MCI | Denver – Kansas City | 560 |
| ORD–SAN | Chicago – San Diego | 559 |
| ORD–RDU | Chicago – Raleigh/Durham | 548 |
| ORD–XNA | Chicago – Fayetteville/Springdale/Rogers | 544 |
| MIA–ORD | Miami – Chicago | 540 |
| ORD–STL | Chicago – St Louis | 539 |
| ORD–PIT | Chicago – Pittsburgh | 538 |
| MKE–ORD | Milwaukee – Chicago | 534 |
| LAX–LHR | Los Angeles – London | 528 |
| EWR–MCO | Newark – Orlando | 525 |
| OKC–ORD | Oklahoma City – Chicago | 515 |
| MEM–ORD | Memphis – Chicago | 514 |
| CLE–ORD | Cleveland – Chicago | 512 |
| CVG–EWR | Cincinnati / Covington – Newark | 508 |
| IAH–LGA | Houston – New York | 506 |
| MSN–ORD | Madison – Chicago | 504 |
| IAH–LAX | Houston – Los Angeles | 500 |
| DEN–PDX | Denver – Portland | 497 |
| DEN–IAH | Denver – Houston | 493 |
| YLW–YVR | Kelowna – Vancouver | 491 |
| DFW–EWR | Dallas-Fort Worth – Newark | 489 |
| COS–DEN | Colorado Springs – Denver | 487 |
| LAX–YVR | Los Angeles – Vancouver | 487 |
| AUS–DFW | Austin – Dallas-Fort Worth | 486 |
| CLT–IAD | Charlotte – Dulles | 485 |
| GRR–ORD | Grand Rapids – Chicago | 483 |
| GRB–ORD | Green Bay – Chicago | 483 |
| PDX–SFO | Portland – San Francisco | 479 |
| ORD–TUL | Chicago – Tulsa | 479 |
| ORD–SGF | Chicago – Springfield | 471 |
| OMA–ORD | Omaha – Chicago | 468 |
| BOS–DEN | Boston – Denver | 465 |
| AUS–LAX | Austin – Los Angeles | 465 |
| LHR–ORD | London – Chicago | 464 |
| BOS–EWR | Boston – Newark | 464 |
| DTW–EWR | Detroit – Newark | 464 |
| LAX–SLC | Los Angeles – Salt Lake City | 463 |
| EWR–IND | Newark – Indianapolis | 462 |
| DEN–STL | Denver – St Louis | 459 |
| DCA–IAH | Washington – Houston | 457 |
| ORD–RIC | Chicago – Richmond | 456 |
| BNA–DEN | Nashville – Denver | 456 |
| SFO–YYZ | San Francisco – Toronto | 454 |
| DEN–PHL | Denver – Philadelphia | 449 |
| EWR–YYZ | Newark – Toronto | 449 |
| ICT–ORD | Wichita – Chicago | 447 |
| ORD–SDF | Chicago – Louisville | 446 |
| LAX–MCO | Los Angeles – Orlando | 444 |
| LGA–YUL | New York – Montréal | 441 |
| FLL–ORD | Fort Lauderdale – Chicago | 440 |
| FAR–ORD | Fargo – Chicago | 439 |
| SFO–YVR | San Francisco – Vancouver | 436 |
| EWR–LHR | Newark – London | 435 |
| ATL–IAD | Atlanta – Dulles | 434 |