| MEX–MTY | Mexico City – Monterrey | 1,028 |
| CUN–MEX | Cancún – Mexico City | 885 |
| GDL–MEX | Guadalajara – Mexico City | 831 |
| MEX–TIJ | Mexico City – Tijuana | 680 |
| CUN–MTY | Cancún – Monterrey | 551 |
| MEX–MID | Mexico City – Mérida | 527 |
| GDL–TIJ | Guadalajara – Tijuana | 494 |
| GDL–LAX | Guadalajara – Los Angeles | 422 |
| IAH–MEX | Houston – Mexico City | 418 |
| GDL–MTY | Guadalajara – Monterrey | 385 |
| LAX–MEX | Los Angeles – Mexico City | 379 |
| MEX–ORD | Mexico City – Chicago | 357 |
| MEX–PVR | Mexico City – Puerto Vallarta | 335 |
| IAH–MTY | Houston – Monterrey | 328 |
| DFW–MTY | Dallas-Fort Worth – Monterrey | 316 |
| CUN–GDL | Cancún – Guadalajara | 307 |
| CUN–NLU | Cancún – Mexico City | 306 |
| JFK–MEX | New York – Mexico City | 305 |
| GDL–NLU | Guadalajara – Mexico City | 293 |
| HMO–MEX | Hermosillo – Mexico City | 289 |
| MEX–SJD | Mexico City – San José del Cabo | 282 |
| CJS–MEX | Ciudad Juárez – Mexico City | 270 |
| CUU–MEX | Chihuahua – Mexico City | 259 |
| MEX–OAX | Mexico City – Oaxaca | 251 |
| MEX–VSA | Mexico City – Villahermosa | 238 |
| MTY–NLU | Monterrey – Mexico City | 218 |
| MEX–VER | Mexico City – Veracruz | 217 |
| MEX–TRC | Mexico City – Torreón | 204 |
| MEX–TGZ | Mexico City – Tuxtla Gutiérrez | 203 |
| MID–NLU | Mérida – Mexico City | 198 |
| CUL–TIJ | Culiacán – Tijuana | 188 |
| MTY–QRO | Monterrey – Querétaro | 186 |
| MIA–MID | Miami – Mérida | 179 |
| BOG–CUN | Bogota – Cancún | 169 |
| MEX–MZT | Mexico City – Mazatlàn | 168 |
| NLU–TIJ | Mexico City – Tijuana | 167 |
| IAH–QRO | Houston – Querétaro | 167 |
| BJX–TIJ | Silao – Tijuana | 164 |
| BJX–IAH | Silao – Houston | 162 |
| BJX–MTY | Silao – Monterrey | 161 |
| MTY–TIJ | Monterrey – Tijuana | 158 |
| MID–MTY | Mérida – Monterrey | 157 |
| CUN–TLC | Cancún – Toluca | 156 |
| LAS–MEX | Las Vegas – Mexico City | 156 |
| MTY–TLC | Monterrey – Toluca | 151 |
| CTM–MEX | Chetumal – Mexico City | 149 |
| MLM–TIJ | Morelia – Tijuana | 140 |
| GDL–LAS | Guadalajara – Las Vegas | 137 |
| MEX–PXM | Mexico City – Puerto Escondido | 137 |
| GDL–ORD | Guadalajara – Chicago | 136 |
| CUN–QRO | Cancún – Querétaro | 136 |
| MEX–SAT | Mexico City – San Antonio | 128 |
| GDL–SJD | Guadalajara – San José del Cabo | 125 |
| LAP–TIJ | La Paz – Tijuana | 125 |
| CUN–PBC | Cancún – Puebla | 125 |
| MTY–ORD | Monterrey – Chicago | 123 |
| BJX–CUN | Silao – Cancún | 123 |
| SJD–TIJ | San José del Cabo – Tijuana | 121 |
| CJS–GDL | Ciudad Juárez – Guadalajara | 119 |
| HUX–MEX | Huatulco – Mexico City | 115 |
| MTY–PVR | Monterrey – Puerto Vallarta | 112 |
| HMO–TIJ | Hermosillo – Tijuana | 110 |
| GDL–MID | Guadalajara – Mérida | 108 |
| NLU–PVR | Mexico City – Puerto Vallarta | 106 |
| PVR–TIJ | Puerto Vallarta – Tijuana | 106 |
| GDL–HMO | Guadalajara – Hermosillo | 104 |
| NLU–TQO | Mexico City – Tulum | 104 |
| PBC–TIJ | Puebla – Tijuana | 102 |
| DFW–QRO | Dallas-Fort Worth – Querétaro | 100 |
| CUL–MTY | Culiacán – Monterrey | 99 |
| MTY–SLP | Monterrey – San Luis Potosí | 99 |
| GDL–VER | Guadalajara – Veracruz | 97 |
| CJS–MTY | Ciudad Juárez – Monterrey | 94 |
| NLU–SJD | Mexico City – San José del Cabo | 93 |
| MZT–TIJ | Mazatlàn – Tijuana | 92 |
| HMO–NLU | Hermosillo – Mexico City | 89 |
| GDL–PBC | Guadalajara – Puebla | 88 |
| MEX–REX | Mexico City – Reynosa | 87 |
| MIA–MTY | Miami – Monterrey | 87 |
| OAX–TIJ | Oaxaca – Tijuana | 86 |
| CUN–VER | Cancún – Veracruz | 86 |
| BJX–DFW | Silao – Dallas-Fort Worth | 85 |
| GDL–PVR | Guadalajara – Puerto Vallarta | 84 |
| GDL–LAP | Guadalajara – La Paz | 82 |
| BOG–NLU | Bogota – Mexico City | 81 |
| CUU–GDL | Chihuahua – Guadalajara | 80 |
| CUN–TGZ | Cancún – Tuxtla Gutiérrez | 78 |
| CUU–MTY | Chihuahua – Monterrey | 75 |
| PVR–TLC | Puerto Vallarta – Toluca | 72 |
| HMO–MTY | Hermosillo – Monterrey | 71 |
| MTY–VER | Monterrey – Veracruz | 71 |
| LAS–MTY | Las Vegas – Monterrey | 71 |
| MTY–PBC | Monterrey – Puebla | 68 |
| CUU–NLU | Chihuahua – Mexico City | 68 |
| NLD–NLU | Nuevo Laredo – Mexico City | 64 |
| GDL–TGZ | Guadalajara – Tuxtla Gutiérrez | 62 |
| MTY–SAT | Monterrey – San Antonio | 60 |
| NLU–VER | Mexico City – Veracruz | 60 |
| SJD–TLC | San José del Cabo – Toluca | 59 |
| MTY–TAM | Monterrey – Ciudad Madero | 58 |
| GDL–VSA | Guadalajara – Villahermosa | 54 |
| CJS–CUN | Ciudad Juárez – Cancún | 53 |
| MZT–NLU | Mazatlàn – Mexico City | 53 |
| DGO–MTY | Durango – Monterrey | 52 |
| NLU–OAX | Mexico City – Oaxaca | 52 |
| MTY–SJD | Monterrey – San José del Cabo | 51 |
| MID–VER | Mérida – Veracruz | 51 |
| CUN–CUU | Cancún – Chihuahua | 50 |
| NLU–ZIH | Mexico City – Ixtapa | 48 |
| BJX–NLU | Silao – Mexico City | 46 |
| BJX–CJS | Silao – Ciudad Juárez | 45 |
| BOG–MTY | Bogota – Monterrey | 45 |
| MID–VSA | Mérida – Villahermosa | 45 |
| NLU–PXM | Mexico City – Puerto Escondido | 44 |
| MTY–MZT | Monterrey – Mazatlàn | 44 |
| CUL–NLU | Culiacán – Mexico City | 44 |
| GDL–REX | Guadalajara – Reynosa | 44 |
| QRO–SAT | Querétaro – San Antonio | 43 |
| MTY–OAX | Monterrey – Oaxaca | 41 |
| MID–TLC | Mérida – Toluca | 40 |