| MEX–MTY | Mexico City – Monterrey | 1,028 |
| CUN–MEX | Cancún – Mexico City | 885 |
| GDL–MEX | Guadalajara – Mexico City | 831 |
| MEX–TIJ | Mexico City – Tijuana | 680 |
| CUN–MTY | Cancún – Monterrey | 551 |
| MEX–MID | Mexico City – Mérida | 527 |
| GDL–TIJ | Guadalajara – Tijuana | 494 |
| GDL–LAX | Guadalajara – Los Angeles | 422 |
| IAH–MEX | Houston – Mexico City | 418 |
| GDL–MTY | Guadalajara – Monterrey | 385 |
| LAX–MEX | Los Angeles – Mexico City | 379 |
| MEX–ORD | Mexico City – Chicago | 357 |
| DFW–MEX | Dallas-Fort Worth – Mexico City | 338 |
| MEX–PVR | Mexico City – Puerto Vallarta | 335 |
| IAH–MTY | Houston – Monterrey | 328 |
| CUN–GDL | Cancún – Guadalajara | 307 |
| CUN–NLU | Cancún – Mexico City | 306 |
| MEX–MIA | Mexico City – Miami | 303 |
| GDL–NLU | Guadalajara – Mexico City | 293 |
| HMO–MEX | Hermosillo – Mexico City | 289 |
| MEX–SJD | Mexico City – San José del Cabo | 282 |
| CJS–MEX | Ciudad Juárez – Mexico City | 270 |
| CUU–MEX | Chihuahua – Mexico City | 259 |
| MEX–OAX | Mexico City – Oaxaca | 251 |
| MEX–VSA | Mexico City – Villahermosa | 238 |
| MEX–VER | Mexico City – Veracruz | 217 |
| GDL–IAH | Guadalajara – Houston | 207 |
| MEX–TGZ | Mexico City – Tuxtla Gutiérrez | 203 |
| LIM–MEX | Lima – Mexico City | 202 |
| MID–NLU | Mérida – Mexico City | 198 |
| CUL–TIJ | Culiacán – Tijuana | 188 |
| MTY–QRO | Monterrey – Querétaro | 186 |
| MCO–MEX | Orlando – Mexico City | 174 |
| MEX–MZT | Mexico City – Mazatlàn | 168 |
| NLU–TIJ | Mexico City – Tijuana | 167 |
| IAH–QRO | Houston – Querétaro | 167 |
| BJX–TIJ | Silao – Tijuana | 164 |
| BJX–MTY | Silao – Monterrey | 161 |
| MTY–TIJ | Monterrey – Tijuana | 158 |
| MID–MTY | Mérida – Monterrey | 157 |
| CUN–TLC | Cancún – Toluca | 156 |
| LAS–MEX | Las Vegas – Mexico City | 156 |
| DEN–MEX | Denver – Mexico City | 153 |
| MTY–TLC | Monterrey – Toluca | 151 |
| CTM–MEX | Chetumal – Mexico City | 149 |
| LAP–MEX | La Paz – Mexico City | 146 |
| DFW–GDL | Dallas-Fort Worth – Guadalajara | 142 |
| GUA–MEX | Guatemala City – Mexico City | 142 |
| MLM–TIJ | Morelia – Tijuana | 140 |
| GDL–LAS | Guadalajara – Las Vegas | 137 |
| MEX–PXM | Mexico City – Puerto Escondido | 137 |
| GDL–ORD | Guadalajara – Chicago | 136 |
| CUN–QRO | Cancún – Querétaro | 136 |
| MEX–MXL | Mexico City – Mexicali | 133 |
| GDL–OAK | Guadalajara – Oakland | 132 |
| MEX–SAT | Mexico City – San Antonio | 128 |
| GDL–PHX | Guadalajara – Phoenix | 126 |
| GDL–SJD | Guadalajara – San José del Cabo | 125 |
| LAP–TIJ | La Paz – Tijuana | 125 |
| CUN–PBC | Cancún – Puebla | 125 |
| LMM–MEX | Los Mochis – Mexico City | 124 |
| BJX–CUN | Silao – Cancún | 123 |
| SJD–TIJ | San José del Cabo – Tijuana | 121 |
| CJS–GDL | Ciudad Juárez – Guadalajara | 119 |
| MEX–SAL | Mexico City – San Salvador (San Luis Talpa) | 119 |
| CUL–MEX | Culiacán – Mexico City | 117 |
| ACA–MEX | Acapulco – Mexico City | 115 |
| HUX–MEX | Huatulco – Mexico City | 115 |
| MTY–PVR | Monterrey – Puerto Vallarta | 112 |
| CZM–MEX | Cozumel – Mexico City | 111 |
| IAH–SLP | Houston – San Luis Potosí | 110 |
| MEX–ZIH | Mexico City – Ixtapa | 110 |
| HMO–TIJ | Hermosillo – Tijuana | 110 |
| CUL–GDL | Culiacán – Guadalajara | 109 |
| GDL–MID | Guadalajara – Mérida | 108 |
| MEX–TAP | Mexico City – Tapachula | 106 |
| PVR–TIJ | Puerto Vallarta – Tijuana | 106 |
| GDL–HMO | Guadalajara – Hermosillo | 104 |
| GDL–SMF | Guadalajara – Sacramento | 102 |
| PBC–TIJ | Puebla – Tijuana | 102 |
| DFW–QRO | Dallas-Fort Worth – Querétaro | 100 |
| CUL–MTY | Culiacán – Monterrey | 99 |
| MTY–SLP | Monterrey – San Luis Potosí | 99 |
| GDL–VER | Guadalajara – Veracruz | 97 |
| FAT–GDL | Fresno – Guadalajara | 96 |
| NLU–SJD | Mexico City – San José del Cabo | 93 |
| MZT–TIJ | Mazatlàn – Tijuana | 92 |
| CUN–TIJ | Cancún – Tijuana | 90 |
| GDL–MXL | Guadalajara – Mexicali | 88 |
| GDL–PBC | Guadalajara – Puebla | 88 |
| GDL–SJC | Guadalajara – San Jose | 87 |
| OAX–TIJ | Oaxaca – Tijuana | 86 |
| GDL–PVR | Guadalajara – Puerto Vallarta | 84 |
| GDL–LAP | Guadalajara – La Paz | 82 |
| BOG–NLU | Bogota – Mexico City | 81 |
| CUU–GDL | Chihuahua – Guadalajara | 80 |
| GDL–ONT | Guadalajara – Ontario | 79 |
| CUN–TGZ | Cancún – Tuxtla Gutiérrez | 78 |
| GDL–TLC | Guadalajara – Toluca | 77 |
| GDL–SLC | Guadalajara – Salt Lake City | 75 |
| LMM–TIJ | Los Mochis – Tijuana | 74 |
| DGO–TIJ | Durango – Tijuana | 72 |
| PVR–TLC | Puerto Vallarta – Toluca | 72 |
| AGU–TIJ | Aguascalientes – Tijuana | 70 |
| IAH–PBC | Houston – Puebla | 70 |
| CUU–TIJ | Chihuahua – Tijuana | 68 |
| CUN–GUA | Cancún – Guatemala City | 64 |
| QRO–TIJ | Querétaro – Tijuana | 63 |
| IAH–MLM | Houston – Morelia | 63 |
| GDL–TGZ | Guadalajara – Tuxtla Gutiérrez | 62 |
| GDL–SEA | Guadalajara – Seattle | 61 |
| SJD–TLC | San José del Cabo – Toluca | 59 |
| CLQ–TIJ | Colima – Tijuana | 57 |
| GDL–PDX | Guadalajara – Portland | 56 |
| BJX–PVR | Silao – Puerto Vallarta | 56 |
| DFW–MLM | Dallas-Fort Worth – Morelia | 54 |
| CUN–SJO | Cancún – San José (Alajuela) | 54 |
| GDL–SAT | Guadalajara – San Antonio | 54 |
| GDL–VSA | Guadalajara – Villahermosa | 54 |
| MDW–MLM | Chicago – Morelia | 53 |
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